Obesity, waist circumference, weight change, and the risk of psoriasis in women - Nurses' health study II
Obesity, waist circumference, weight change, and the risk of psoriasis in women - Nurses' health study II
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DOI：
10.1001/archinte.167.15.1670
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发表时间：
2007-08-13
影响因子：
--
通讯作者：
Choi, Hyon K.
中科院分区：
文献类型：
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作者：
Setty, Arathi R.;Curhan, Gary;Choi, Hyon K.
背景：银屑病是一种常见的慢性炎症性皮肤病。肥胖可能会增加银屑病的风险，但据我们所知，没有关于这种关系的前瞻性数据。方法：我们前瞻性地检查了体重指数与（BMI [计算方法为体重（千克）除以身高（米）的平方]）、体重变化、腰围、臀围、腰臀比，在护士健康研究II中，78626名女性在14年期间（1991-2005）发生银屑病。主要结果是事件，自我报告，医生诊断的psorias.Results：在14年的后续行动，有892例自我报告的事件银屑病。在多个时间点测量的BMI与银屑病发病风险之间存在分级正相关。当我们分析每2年更新一次的BMI时，与BMI为21.0 - 22.9相比，银屑病的多变量相对危险度为1.40（95%置信区间[CI]，1.13-1.73），BMI为25.0 - 29.9; 1.48（95% CI，1.15-1.91），BMI为30.0 - 34.9; 2.69（95% CI，2.12-3.40）BMI ≥ 35.0（趋势P = 30.0）为1.73（95% CI，1.24-2.41），较低BMI类别（< 21.0）为0.76（95% CI，0.65-0.90）（趋势P，
Background: Psoriasis is a common, chronic, inflammatory skin disorder. Higher adiposity may increase the risk of psoriasis, but, to our knowledge, no prospective data are available on this relationship.Methods: We prospectively examined the relationships between body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight change, waist circumference, hip circumference, waist-hip ratio, and incident psoriasis in 78 626 women over a 14-year period (1991-2005) in the Nurses' Health Study II. The primary outcome was incident, self-reported, physician-diagnosed psoriasis.Results: During the 14 years of follow-up, there were 892 self-reported incident cases of psoriasis. There was a graded positive association between BMI measured at multiple time points and the risk of incident psoriasis. When we analyzed BMI updated every 2 years, compared with a BMI of 21.0 through 22.9, the multivariate relative risks of psoriasis were 1.40 (95% confidence interval [CI], 1.13-1.73) for a BMI of 25.0 through 29.9; 1.48 (95% CI, 1.15-1.91) for a BMI of 30.0 through 34.9; and 2.69 ( 95% CI, 2.12-3.40) for a BMI of 35.0 or greater (P for trend, = 30.0) was 1.73 (95% CI, 1.24-2.41) and that for a lower BMI category (< 21.0) was 0.76 (95% CI, 0.65-0.90) (P for trend,