Priority list of research areas for radiological nuclear threat countermeasures.
Priority list of research areas for radiological nuclear threat countermeasures.
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DOI：
10.1667/rr3283
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发表时间：
2005-01-01
影响因子：
3.4
通讯作者：
Rockwell, Sara
中科院分区：
文献类型：
--
作者：
Pellmar, Terry C;Rockwell, Sara
为了帮助国家为可能使用放射性和核装置的恐怖袭击做好准备，科学和技术政策办公室和国土安全理事会成立了一个机构间工作组。工作组审议了放射性/核威胁对策的研究需要，确定了18个需要进一步关注的领域并确定了优先次序。最优先考虑的研究是（1）暴露前使用的辐射防护剂;（2）暴露后治疗的治疗剂;（3）与辐射暴露相关的感染的抗菌治疗;（4）细胞因子和生长因子;（5）分子、细胞、组织和生物体水平的辐射损伤机制;和（6）生物剂量测定的自动化。高度优先考虑的是：（1）开发生物剂量学生物标志物;（2）加强辐射科学培训;（3）探索复合损伤的后果;（4）建立关于调查对策的信息库;（5）跟踪受照射人群的健康状况，以便为随后的事件做好更好的准备。本报告描述了委员会认为需要辐射研究界关注的研究领域，旨在向该界通报国家的需求，并鼓励研究人员解决这些关键问题。
To help the nation prepare for the possibility of a terrorist attack using radiological and nuclear devices, the Office of Science and Technology Policy and the Homeland Security Council established an interagency working group. The working group deliberated on the research needs for radiological/ nuclear threat countermeasures and identified and prioritized 18 areas for further attention. The highest priorities were given to research on (1) radioprotectors for use prior to exposure; (2) therapeutic agents for postexposure treatment; (3) antimicrobial therapy for infections associated with radiation exposure; (4) cytokines and growth factors; (5) mechanisms of radiation injury at the molecular, cellular, tissue and organism levels; and (6) automation of biodosimetric assays. High priority was given to (1) developing biomarkers for biodosimetry; (2) enhancing training in the radiation sciences; (3) exploring the consequences of combined injury; (4) establishing a repository of information regarding investigational countermeasures; and (5) following the health of an exposed population to better prepare for subsequent events. The research areas that the committee felt required the attention of the radiation research community are described in this report in an effort to inform this community about the needs of the nation and to encourage researchers to address these critical issues.