Analysis of sodium carboxymethylcellulose administration and related factors associated with postoperative colic and survival in horses with small intestinal disease
Analysis of sodium carboxymethylcellulose administration and related factors associated with postoperative colic and survival in horses with small intestinal disease
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DOI：
10.1111/j.1532-950x.2008.00420.x
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发表时间：
2008-08-01
影响因子：
1.8
通讯作者：
Blikslager, Anthony T.
中科院分区：
文献类型：
--
作者：
Fogle, Callie A.;Gerard, Mathewp.;Blikslager, Anthony T.
目的-分析术中使用羧甲基纤维素钠（CBMC）和相关围手术期因素对腹部手术治疗肠绞痛的马术后肠绞痛和存活率的影响。33匹马术中给予CBMC。从使用CBMC前接受绞痛手术的170匹马和术中接受CBMC的33匹马的病历中获得信息。Kaplan-Meier生存曲线被用来估计中位生存时间和考克斯比例风险模型被用来估计CBMC和其他围手术期变量对survival.Results的影响的风险比-百分之七十五的马CBMC管理存活到180天，而75%的未经处理的马存活8天（中位生存时间=18天）。未给予CBMC的马死亡的可能性是给予CBMC的马的两倍。有术后肠梗阻（POI）的马死亡的可能性是没有肠梗阻的马的1.4倍。同样，马手术后绞痛的迹象是1.3倍，更有可能死亡的马没有术后迹象colic.Conclusions - CBMC管理似乎是防止死亡和存活期的马小肠疾病，特别是马手术后绞痛或POI术中使用。POI和绞痛增加了手术后死亡的风险。临床相关性-在手术治疗小肠疾病的马中术中给予CBMC可能通过减少早期粘连形成来提高生存率。(C)版权所有2008年由美国兽医学院。
Objective - To analyze the effect of the intraoperative use of sodium carboxymethylcellulose (CBMC) and related perioperative factors on postoperative colic and survival in horses that had abdominal surgery for colic.Study Design - Retrospective study.Animals - Horses (n=203) that had surgery for small intestinal disease; 33 horses had intraoperative administration of CBMC.Methods - Information was obtained from medical records for 170 horses that had surgery for colic before use of CBMC and 33 horses that had intraoperative CBMC. Kaplan-Meier survival curves were used to estimate median survival time and a Cox proportional hazards model was used to estimate the hazard ratio for the effect of CBMC and other perioperative variables on survival.Results - Seventy-five percent of horses administered CBMC survived to 180 days, whereas 75% of untreated horses survived 8 days (median survival time=18 days). Horses not administered CBMC were twice as likely to die compared with horses administered CBMC. Horses that had postoperative ileus (POI) were 1.4 times more likely to die than horses without ileus. Similarly, horses with signs of colic after surgery were 1.3 times more likely to die than horses without postoperative signs of colic.Conclusions - CBMC administration is seemingly protective against death and prolongs survival when used intraoperatively in horses with small intestine disease, particularly horses with postoperative colic or POI. Both POI and colic increased risk of death after surgery.Clinical Relevance - Intraoperative administration of CBMC in horses that have surgery for small intestinal disease may improve survival, possibly by reducing early adhesion formation. (C) Copyright 2008 by The American College of Veterinary Surgeons.