Time-dependent changes in alcohol-seeking behaviour during abstinence
Time-dependent changes in alcohol-seeking behaviour during abstinence
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DOI：
10.1016/j.euroneuro.2003.10.005
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发表时间：
2004-10-01
影响因子：
5.6
通讯作者：
Kostowski, W
中科院分区：
文献类型：
--
作者：
Bienkowski, P;Rogowski, A;Kostowski, W
即使在长期戒酒之后，酒精成瘾者接触与酒精相关的环境因素也可能会引发饮酒行为。本研究的目的是评估经过训练对酒精做出反应的大鼠的寻酒行为随时间的变化。戒断1、28或56天后，将大鼠重新暴露于与酒精相关的刺激。在重新暴露过程中，首先让老鼠做出灭绝反应。然后，一系列离散的与酒精相关的线索（听觉和光线线索与酒精的味道和气味相结合）会唤起寻求酒精的行为的恢复。消退行为取决于禁欲持续时间，28 天禁欲后反应最大。戒酒 56 天后，由离散线索诱发的饮酒行为恢复率最高。没有发现个体酒精摄入量、消退行为和提示诱导的恢复之间存在相关性。这些结果表明：（i）长期强制戒酒后，酗酒行为可能会变得更加强烈； (ii) 酒精的自我管理、消退行为和酗酒行为的恢复可能受到单独的神经机制的调节。 (C) 2003 Elsevier B.V. 和 ECNP。版权所有。
Exposure of alcohol addicts to alcohol-related environmental cues may elicit alcohol-seeking behaviour even after protracted abstinence. The purpose of the present study was to assess time-dependent changes in alcohol-seeking behaviour in rats trained to respond for alcohol. The rats were re-exposed to alcohol-associated stimuli after 1, 28 or 56 days of withdrawal. During the re-exposure session, the rats were first allowed to respond in extinction. Then, reinstatement of alcohol-seeking behaviour was evoked by a complex of discrete alcohol-associated cues (auditory and light cues combined with taste and smell of alcohol). Extinction behaviour depended on abstinence duration with maximal responding after 28-day abstinence. Reinstatement of alcohol-seeking behaviour evoked by the discrete cues was highest after 56-day abstinence. No correlations were found between individual alcohol intakes, extinction behaviour and cue-induced reinstatement. These results suggest that: (i) alcohol-seeking behaviour may become more intense after long-term imposed abstinence; (ii) alcohol self-administration, extinction behaviour, and reinstatement of alcohol-seeking behaviour may be regulated by separate neural mechanisms. (C) 2003 Elsevier B.V. and ECNP. All rights reserved.