Effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone.
Effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone.
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omega-3、omega-6 和 omega-9 脂肪酸对血管平滑肌张力的影响。
DOI：
10.1016/0014-2999(92)90050-e
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发表时间：
1992
影响因子：
5
通讯作者：
M. Engler
中科院分区：
文献类型：
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作者：
M. Engler
研究了欧米茄-3、欧米茄-6和欧米茄-9脂肪酸对血管平滑肌张力的比较影响。二十二碳六烯酸（1-255 μM）和二十碳五烯酸（31-255 μM）分别抑制苯肾上腺素诱导的收缩（8-63%）和（20-65%），而吲哚美辛、NDGA或去除内皮均不改变这一点。亚油酸（18：2n 6）和花生四烯酸（20：4 n6）也引起显著的舒张。因此，脂肪酸诱导的大鼠主动脉舒张是特定的多不饱和脂肪酸，20：5 n3，22：6 n3，18：2n 6和20：4 n6。
The comparative effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone were investigated. Docosahexaenoic acid (1–255 μM) and eicosapentaenoic acid (31–255 μM) inhibited phenylephrine-induced contractions, (8–63%) and (20–65%), respectively, which were not altered by indomethacin, NDGA, or by removal of the endothelium. Linoleic acid (18:2n6) and arachidonic acid (20:4n6) also induced significant relaxation. Therefore, fatty acid-induced relaxation of the rat aorta is specific to polyunsaturated fatty acids, 20:5n3, 22:6n3, 18:2n6 and 20:4n6.