CD57 in human natural killer cells and T-lymphocytes
CD57 in human natural killer cells and T-lymphocytes
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DOI：
10.1007/s00262-016-1803-z
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发表时间：
2016-04-01
影响因子：
5.8
通讯作者：
Larbi, Anis
中科院分区：
文献类型：
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作者：
Kared, Hassen;Martelli, Serena;Larbi, Anis
CD 57抗原（或者HNK-1、LEU-7或L2）通常用于鉴定增殖能力降低和功能特性改变的终末分化的“衰老”细胞。在这篇文章中，我们回顾了目前对表达CD 57的T细胞和NK细胞在健康和疾病中的属性的理解，并讨论了这种标志物如何告知研究人员它们在人体血液和组织中的可能功能。虽然人淋巴细胞上的CD 57表达表明不能增殖，但这些细胞也显示出高细胞毒性潜力，并且CD 57（pos）NK细胞表现出记忆样特征和有效的效应子功能。因此，血液和组织中表达CD 57的细胞的频率与慢性感染或各种癌症的临床预后以及人类衰老相关。因此，衰老的CD 57（pos）T细胞和成熟的CD 57（pos）NK细胞的功能调节可以代表针对人类免疫老化和/或各种慢性疾病的保护的创新策略。
The CD57 antigen (alternatively HNK-1, LEU-7, or L2) is routinely used to identify terminally differentiated 'senescent' cells with reduced proliferative capacity and altered functional properties. In this article, we review current understanding of the attributes of CD57-expressing T-cells and NK cells in both health and disease and discuss how this marker can inform researchers about their likely functions in human blood and tissues in vivo. While CD57 expression on human lymphocytes indicates an inability to proliferate, these cells also display high cytotoxic potential, and CD57(pos) NK cells exhibit both memory-like features and potent effector functions. Accordingly, frequencies of CD57-expressing cells in blood and tissues have been correlated with clinical prognosis in chronic infections or various cancers and with human aging. Functional modulation of senescent CD57(pos) T-cells and mature CD57(pos) NK cells may therefore represent innovative strategies for protection against human immunological aging and/or various chronic diseases.