Increased extracellular clusterin in the prefrontal cortex in schizophrenia.
Increased extracellular clusterin in the prefrontal cortex in schizophrenia.
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DOI：
10.1016/j.schres.2015.10.002
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发表时间：
2015-12
影响因子：
4.5
通讯作者：
Woo TW
中科院分区：
文献类型：
--
作者：
Athanas KM;Mauney SL;Woo TW
编码丛生蛋白的基因的表达，一种糖蛋白，已被牵连在许多细胞过程的调节中，先前已被发现在基因表达谱研究是最显着差异表达的基因在锥体和小清蛋白抑制性神经元在大脑皮层中的精神分裂症的主题。在这项研究中，我们调查是否clusterin也可能在蛋白质水平失调，精神分裂症患者。我们发现，虽然细胞内聚集蛋白的量可能是不变的，细胞外分泌的聚集蛋白的水平似乎显着增加精神分裂症受试者。据推测，这一发现可能代表了精神分裂症基础的病理生理事件的神经保护反应。
The expression of the gene that encodes clusterin, a glycoprotein that has been implicated in the regulation of many cellular processes, has previously been found in gene expression profiling studies to be among the most significantly differentially expressed genes in pyramidal and parvalbumin-containing inhibitory neurons in the cerebral cortex in subjects with schizophrenia. In this study, we investigated whether clusterin may also be dysregulated at the protein level in schizophrenia subjects. We found that, although the intracellular amount of clusterin may be unchanged, the level of extracellular, secreted clusterin appears to be significantly increased in schizophrenia subjects. It is speculated that this finding may represent a neuroprotective response to pathophysiological events that underlie schizophrenia.