Efficacy of botulinum toxin in severe Tourette syndrome with dystonic tics involving the neck
Efficacy of botulinum toxin in severe Tourette syndrome with dystonic tics involving the neck
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DOI：
10.1016/j.parkreldis.2007.10.007
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发表时间：
2008-01-01
影响因子：
4.1
通讯作者：
Kulisevsky, Jaime
中科院分区：
文献类型：
--
作者：
Aguirregomozcorta, Maria;Pagonabarraga, Javier;Kulisevsky, Jaime
严重的张力障碍性抽搐涉及颈部可能导致严重的脊柱疾病的发展。抽搐的药物治疗可缓解症状，但严重抽搐的临床相关改善并不常见，可能导致严重不良事件。肉毒杆菌毒素（BnT）似乎是一种安全有效的治疗抽搐，但一些关注存在哪些患者可能受益于治疗。我们报告一个受Tourette综合征影响的患者，四肢轻瘫和颈椎病继发于颈部的剧烈张力障碍性抽搐，其中一个更积极的治疗过程中，BnT除了抗精神病药物治疗，导致完全解决颈椎抽搐后12个月的随访。(C)2008爱思唯尔有限公司保留所有权利。
Severe dystonic tics involving the neck may lead to the development of serious spine disease. The pharmacological treatment of tics offers symptomatic relief, but clinically relevant improvement of severe tics is not frequently achieved and serious adverse events may result. Botulinum toxin (BnT) appears to be a safe and effective treatment for tics, but some concern exists about which group of patients may benefit from treatment. We report a patient affected by Tourette syndrome with tetraparesis and cervical myelopathy secondary to violent dystonic tics involving the neck, in which a more aggressive course of treatment with BnT in addition to neuroleptic medication resulted in complete resolution of cervical tics after 12 months of follow-up. (C) 2008 Elsevier Ltd. All rights reserved.