ARHI, As a Novel Suppressor of Cell Growth and Downregulated in Human Hepatocellular Carcinoma, Could Contribute to Hepatocarcinogenesis
ARHI, As a Novel Suppressor of Cell Growth and Downregulated in Human Hepatocellular Carcinoma, Could Contribute to Hepatocarcinogenesis
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DOI：
10.1002/mc.20461
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发表时间：
2009-02-01
影响因子：
4.6
通讯作者：
Han, Ze-guang
中科院分区：
文献类型：
--
作者：
Huang, Jian;Lin, Yun;Han, Ze-guang
寻找在肝细胞癌中差异表达的癌基因，对于了解肝癌发生的分子机制具有重要意义。实时定量RT-PCR检测42例肝细胞癌组织中ARHI基因的表达，其中33例(78.6%)明显低于癌旁肝组织(P<0.05)。
The identification of cancer genes differentially expressed in hepatocellular carcinoma (HCC) plays an important role in understanding the molecular mechanisms of hepatocarcinogenesis. Here, ARHI gene expression was analyzed by real-time RT-PCR and it was significantly downregulated in 33 of the 42 (78.6%, more than two folds) HCC specimens compared with adjacent noncancerous livers (P