Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells
Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells
复制标题
视黄酸通过下调癌症相关成纤维细胞中的 IL-6 来抑制胰腺癌细胞迁移和 EMT。
DOI：
10.1016/j.canlet.2013.12.006
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发表时间：
2014-04-01
期刊：
影响因子：
9.7
通讯作者：
Chen, Jie
中科院分区：
文献类型：
--
作者：
Guan, Jian;Zhang, Hui;Chen, Jie
维甲酸（RA）是维生素A的小分子衍生物，储存在胰腺基质中的静止星状细胞中。癌相关成纤维细胞（CAF）是胰腺导管腺癌肿瘤微环境中活化的成纤维细胞。我们用RA处理CAF，发现这些细胞由于α-SMA、FAP和IL-6的低表达以及细胞外基质（ECM）的产生减少而变得静止。此外，我们证实，从CAFs的低分泌IL-6有关RA诱导的肿瘤细胞的迁移和上皮间质转化（EMT）的抑制。但RA不能直接抑制肿瘤细胞的迁移和EMT。因此，我们的研究表明，RA对肿瘤细胞的治疗作用之一是通过调节肿瘤微环境中的CAFs。肿瘤微环境在促进肿瘤迁移中起重要作用，可能是一个有前途的生物治疗靶点。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Retinoic acid (RA) is a small molecular derivative of vitamin A that is stored in quiescent stellate cells in pancreas stroma. Cancer associated fibroblasts (CAFs) are activated fibroblast cells in pancreatic ductal adenocarcinoma tumor microenvironment We treated CAFs with RA and found that these cells became static due to the low expression of oc-SMA, FAP, and IL-6 and decreased production of extracellular matrix (ECM). Furthermore, we verified that the low secretion of IL-6 from CAFs was related to RA-induced inhibition of migration and epithelial-mesenchymal transition (EMT) of tumor cells. However, RA could not inhibit the migration and EMT of tumor cells directly. Therefore, our study showed that one of the therapeutic effects of RA on tumor cells is through its modulation of CAFs in tumor microenvironment The tumor microenvironment plays an important role in promoting tumor migration and might be a promising target of biological treatment. (C) 2013 Elsevier Ireland Ltd. All rights reserved.