KINETICS OF HUMAN CONNECTING PEPTIDE IN NORMAL AND DIABETIC SUBJECTS
KINETICS OF HUMAN CONNECTING PEPTIDE IN NORMAL AND DIABETIC SUBJECTS
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DOI：
10.1172/jci109106
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发表时间：
1978-01-01
影响因子：
15.9
通讯作者：
ROSSING, N
中科院分区：
文献类型：
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作者：
FABER, OK;HAGEN, C;ROSSING, N
采用单剂量注射技术测定了6名正常人和7名糖尿病患者的合成人连接肽（C肽）代谢清除率（MCR），并采用恒定输注技术测定了1名正常人的MCR。C肽的MCR在正常受试者（4.4 ml/min/kg;范围，3.7 - 4.9）和糖尿病受试者（4.7 ml/min/kg;范围，3.7 - 5.8）中无差异。在1例受试者中使用两种技术得到了相似的MCR。从研究的单剂量注射的最后1小时期间计算的血浆中C肽的平均半衰期在胰岛素依赖型糖尿病患者中（42.5分钟;范围，39.4 - 48.5）比在正常受试者中（33.5分钟;范围，24.9 - 45.3）长。β-通过测量外周静脉血浆中的C肽浓度，可以比较正常和胰岛素依赖型糖尿病患者的细胞分泌能力。糖尿病患者和正常人之间血浆中C肽半衰期的差异表明肽消失的动力学改变，而由MCR表示的总体代谢是相似的。
The metabolic clearance rate (MCR) of synthetic human connecting peptide (C-peptide) was measured with a single-dose injection technique in 6 normal and 7 diabetic subjects and with a constant infusion technique in 1 normal subject. The MCR of C-peptide did not differ in normal subjects (4.4 ml/min per kg; range, 3.7-4.9) and in diabetic subjects (4.7 ml/min per kg; range, 3.7-5.8). Employment of both techniques in 1 subject gave similar MCR. The average half-life of C-peptide in plasma calculated from the last 1-h period of the single-dose injection studied was longer in the insulin-dependent diabetics (42.5 min; range, 39.4-48.5) than in the normal subjects (33.5 min; range, 24.9-45.3). The .beta.-cell secretory capacity of normal and insulin-dependent diabetic subjects can be compared by measuring the C-peptide concentration in peripheral venous plasma. The difference in the half-life of C-peptide in plasma between diabetics and normals suggested an altered kinetics of the disappearance of the peptide, while the overall metabolism, as expressed by the MCR, is similar.