Interleukin-4 (IL-4) pathway.
Interleukin-4 (IL-4) pathway.
复制标题
DOI：
10.1126/stke.2932005cm9
复制
发表时间：
2005-07-19
期刊：
影响因子：
--
通讯作者：
Keegan, Achsah D
中科院分区：
文献类型：
--
作者：
Kelly-Welch, Ann;Hanson, Erica M;Keegan, Achsah D
白细胞介素-4（IL-4）是由T（H）2型辅助性T细胞以及肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞产生的细胞因子。这种细胞因子可以引起许多反应，其中一些与过敏和哮喘有关。对长期细胞系和原代细胞的研究揭示了这两种实验系统之间的信号传导差异。了解这些差异很重要，因为目前正在测试针对IL-4及其信号通路的治疗策略以治疗过敏和哮喘。
Interleukin-4 (IL-4) is a cytokine produced by T(H)2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between these two experimental systems. Understanding these differences is important because therapeutic strategies targeting IL-4 and its signaling pathways are currently being tested to treat allergy and asthma.