Analysis of influenza A virus reinfection in children in Japan during 1983–91
Analysis of influenza A virus reinfection in children in Japan during 1983–91
复制标题
1983-91年日本儿童甲型流感病毒再感染分析
DOI：
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发表时间：
1995
影响因子：
4.2
通讯作者：
K. Nakajima
中科院分区：
文献类型：
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作者：
S. Nakajima;F. Nishikawa;K. Nakamura;K. Nakajima
对1979 - 1991年日本甲型流感流行病学进行了研究，并对1983 - 1991年再感染分离的病毒进行了分析，在此期间分离的2963株流感病毒中，分别有922株为甲型H1N1流感病毒，1006株为甲型H3N2流感病毒；其他的是乙型流感病毒。甲型H1N1流感和甲型H3N2流感分别引起5次和6次流行，多数伴有抗原漂移。在我们的研究中发现17例H1N1再感染和17例H3N2再感染。对7例H1N1和10例H3N2的原感染株和再感染株进行血凝抑制、血凝素HA1区氨基酸和核苷酸序列分析。大多数原发和再感染毒株在抗原性和遗传上与当时流行的流行病毒相似。然而，在10例H3N2流感病毒再感染病例中，有4例再感染毒株与流行病毒基因不同。
Summary The epidemiology of influenza A in Japan was studied during 1979–91 and viruses isolated from reinfections during 1983–91 were analysed, Of 2963 influenza viruses isolated during this period, 922 and 1006 were influenza A(H1N1) and A(H3N2) viruses respectively; the others were influenza B viruses. Influenza A(H1N1) and A(H3N2) caused 5 and 6 epidemics respectively, most accompanied by antigenic drift. Seventeen reinfections with H1N1 and 17 with H3N2 were detected during our study. The primary and reinfection strains isolated from 7 H1N1 and 10 H3N2 cases were studied by haemagglutination-inhibition, and amino acid and nucleotide sequences of the HA1 region of the haemagglutinin. Most of the primary and reinfection strains were antigenically and genetically similar to the epidemic viruses circulating at that time. However, in 4 out of 10 cases of reinfection with influenza H3N2 virus, reinfection strains were genetically different from the epidemic viruses.