EXPRESSION OF MATRIX METALLOPROTEINASE-3 STAGE-I AND STAGE-II SQUAMOUS-CELL CARCINOMA OF THE ORAL CAVITY
EXPRESSION OF MATRIX METALLOPROTEINASE-3 STAGE-I AND STAGE-II SQUAMOUS-CELL CARCINOMA OF THE ORAL CAVITY
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DOI：
10.1016/0278-2391(95)90065-9
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发表时间：
1995-05-01
影响因子：
1.9
通讯作者：
KAMEYAMA, T
中科院分区：
文献类型：
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作者：
KUSUKAWA, J;SASAGURI, Y;KAMEYAMA, T
目的：为探讨基质金属蛋白酶-3（matrix metalloproteinase-3，MMP-3）在口腔早期鳞状细胞癌（squamous cell carcinoma，SCC）侵袭和转移中的意义，本研究选取65例Ⅰ、Ⅱ期口腔鳞癌患者的手术标本，采用免疫组化法检测MMP-3的表达。结果：65例中MMP-3阳性30例（46.2%），MMP-3阳性表达见于浸润前沿的癌巢，而在正常口腔黏膜中无表达。MMP-3表达与肿瘤大小、浸润深度、浸润方式、淋巴结转移率呈正相关。含有MMP-3的肿瘤会更积极地侵入邻近的正常组织，包括淋巴管和血管，因此，对MMP-3在活检标本中的表达可提供有助于预测口腔早期SCC恶性潜能的信息。
Purpose: The object of this study was to evaluate the significance of matrix metalloproteinase-3 (MMP-3) in tumor invasion and metastasis of early squamous cell carcinoma (SCC) of the oral cavity.Materials and Methods, Surgical specimens from 65 patients with stage I and II SCC of the oral cavity were the subjects of this study. Tissue specimens were fixed in formalin and embedded in paraffin, and the sections were stained with monospecific antibodies against human MMP-3 by the avidin-biotin-peroxidase complex method.Results: Of the 65 patients, 30 (46.2%) tested positive for MMP-3, Immunoreactivity revealed the expression of MMP-3 to be in the small cancer nests in the advancing front of invasion, but not in normal oral epithelium. MMP-3 expression was positively correlated with tumor size, depth of tumor invasion, diffuse invasive mode, and the high incidence of lymph node metastasis.Conclusion: MMP-3-containing tumors will invade adjacent normal tissues more aggressively, including lymphatic and blood vessels, Therefore, the examination of MMP-3 expression in biopsy specimens should provide information useful in predicting the malignant potential of early SCC of the oral cavity.