Differential regulation of epidermal langerhans cell migration by interleukins (IL)-1alpha and IL-1beta during irritant- and allergen-induced cutaneous immune responses.
Differential regulation of epidermal langerhans cell migration by interleukins (IL)-1alpha and IL-1beta during irritant- and allergen-induced cutaneous immune responses.
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在刺激物和过敏原诱导的皮肤免疫反应过程中，白细胞介素 (IL)-1α 和 IL-1β 对表皮朗格汉斯细胞迁移的差异调节。
DOI：
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发表时间：
2002
影响因子：
3.8
通讯作者：
I. Kimber
中科院分区：
文献类型：
--
作者：
M. Cumberbatch;R. Dearman;R. Groves;C. Antonopoulos;I. Kimber
Tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-18 are all known to contribute to the regulation of epidermal Langerhans cells (LC) migration and the subsequent accumulation of dendritic cells (DC) in draining lymph nodes following skin sensitization. However, the cytokine signals that control these responses following skin irritation have yet to be defined. We demonstrate that IL-1alpha, a cytokine associated with skin injury and inflammation, is able to stimulate the activation and migration from the epidermis of LC and their subsequent accumulation in skin-draining lymph nodes. Stimulation of these responses by IL-1alpha required the local availability of TNF-alpha. Using specific neutralizing antibodies, LC migration induced following skin sensitization with oxazolone (Ox) was found to be dependent upon IL-1beta and independent of a requirement for IL-1alpha. However, the converse was true following stimulation of responses with the nonsensitizing skin irritant sodium lauryl sulfate (SLS). Here, the loss of LC from the epidermis and the accumulation of DC in draining lymph nodes required IL-1alpha and not IL-1beta. Despite utilizing different IL-1 isoforms for LC mobilization, the phenotypic characteristics of DC arriving in draining lymph nodes in response to Ox and SLS were similar with respect to the membrane determinants MHC class II, B7-1, B7-2, and intercellular adhesion molecule-1. These data suggest that contact sensitization and skin irritation employ subtly different cytokine networks in the regulation of LC migration, both involving TNF-alpha but demonstrating differential requirements for IL-1 cytokines. The proposal is that different forms of cutaneous trauma may achieve LC migration through distinct molecular mechanisms.
DOI：
10.1073/pnas.92.25.11874
发表时间：
1995-12-05
影响因子：
11.1
作者：
GROVES, RW;MIZUTANI, H;KUPPER, TS
通讯作者：
KUPPER, TS
机械变形促进IL-1α和IL-1受体拮抗剂的分泌。
DOI：
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发表时间：
1997
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lee,RT;Briggs,WH;Cheng,GC;Rossiter,HB;Libby,P;Kupper,T
通讯作者：
Kupper,T