Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair?
Are nestin-positive mesenchymal stromal cells a better source of cells for CNS repair?
复制标题
DOI：
10.1016/j.neuint.2016.08.001
复制
发表时间：
2017-06
影响因子：
4.2
通讯作者：
Barnett SC
中科院分区：
文献类型：
--
作者：
Lindsay SL;Barnett SC
近年来，在干细胞领域进行了大量的研究，从大量的组织和器官中获得了一系列干细胞的定义和分类。干细胞，根据分类，被认为是多能或多能的，具有自我更新和多分化能力。目前，人们对从胚胎和成人组织中分离出的干细胞非常感兴趣，希望它们能成为恢复或治疗中枢神经系统（CNS）疾病中受损细胞的治疗关键。在这篇综述中，我们将讨论从人嗅觉粘膜分离的间充质间质细胞（MSCs）的作用，特别强调它们作为移植介导的中枢神经系统修复的候选细胞的潜在作用。由于巢蛋白的表达决定了整个嗅觉粘膜来源的间充质干细胞群体，我们将把这些细胞与神经嵴来源的巢蛋白阳性骨髓间充质干细胞群体进行比较。人嗅觉粘膜是间充质间质细胞（MSCs）的新来源。一些骨髓间充质干细胞是巢蛋白阳性的，神经嵴衍生并调节造血干细胞的活化。人嗅觉粘膜含有巢蛋白阳性的MSCs，它们分泌CXCL12，可能促进中枢神经系统修复。
In recent years there has been a great deal of research within the stem cell field which has led to the definition and classification of a range of stem cells from a plethora of tissues and organs. Stem cells, by classification, are considered to be pluri- or multipotent and have both self-renewal and multi-differentiation capabilities. Presently there is a great deal of interest in stem cells isolated from both embryonic and adult tissues in the hope they hold the therapeutic key to restoring or treating damaged cells in a number of central nervous system (CNS) disorders. In this review we will discuss the role of mesenchymal stromal cells (MSCs) isolated from human olfactory mucosa, with particular emphasis on their potential role as a candidate for transplant mediated repair in the CNS. Since nestin expression defines the entire population of olfactory mucosal derived MSCs, we will compare these cells to a population of neural crest derived nestin positive population of bone marrow-MSCs. Human olfactory mucosa is a new source of mesenchymal stromal cells (MSCs). Some bone marrow MSCs are nestin-positive, neural crest derived and regulate hematopoietic stem cell activation. Human olfactory mucosa contains a population of nestin-positive MSCs that secrete CXCL12 and may have promote CNS repair.