Radiomics and radiogenomics in pediatric neuro-oncology: A review.
Radiomics and radiogenomics in pediatric neuro-oncology: A review.
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DOI：
10.1093/noajnl/vdac083
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发表时间：
2022-01
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当前的先进计算时代允许放射组学领域的发展和实施。在儿科神经肿瘤学中，放射组学已被应用于确定肿瘤组织学，鉴别播散性疾病，确定肿瘤的分子分类（即放射基因组学）。该领域也面临着许多挑战，例如研究样本量的限制，类别不平衡，方法的普遍性以及成像中心之间的数据协调。本文的目的是双重的：第一，总结现有的文献在儿科神经肿瘤放射组学;第二，提炼的主题和挑战的领域，并讨论在临床和技术方面的未来发展方向。
The current era of advanced computing has allowed for the development and implementation of the field of radiomics. In pediatric neuro-oncology, radiomics has been applied in determination of tumor histology, identification of disseminated disease, prognostication, and molecular classification of tumors (ie, radiogenomics). The field also comes with many challenges, such as limitations in study sample sizes, class imbalance, generalizability of the methods, and data harmonization across imaging centers. The aim of this review paper is twofold: first, to summarize existing literature in radiomics of pediatric neuro-oncology; second, to distill the themes and challenges of the field and discuss future directions in both a clinical and technical context.