Feasibility of ultrasound hyperthermia with waveguide interstitial applicator
Feasibility of ultrasound hyperthermia with waveguide interstitial applicator
复制标题
波导间质治疗器超声热疗的可行性
DOI：
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发表时间：
1996
影响因子：
4.6
通讯作者：
B. Jarosz
中科院分区：
文献类型：
--
作者：
B. Jarosz
间质和腔内超声热疗施加器有助于组织中良好控制的功率沉积。本文介绍了一种用于脑肿瘤治疗的波导治疗器的温升分析和在组织模体、活体动物组织和离体动物组织中的实验结果。它包括一个G18皮下注射针，通过一个锥形速度Transformer连接到一个12.7毫米直径的压电盘，在1.0兆赫操作。轴向声压分布具有4个周期/cm的空间周期性驻波图案。这种周期性是不存在的温度分布在组织幻影。基于有效导热系数方程的模拟结果表明，对于21 mm和60 mm的样品直径，分别在4 mm和10 mm半径范围内可以达到过热范围，并具有合理的输入功率。第一个数字密切对应于5毫米半径观察猪脑在体内和第二个接近9毫米半径在猪脑在体外。所提出的结果表明，超声波波导间质施加器的小体积肿瘤的热疗的潜力。
Interstitial and intracavitary ultrasonic hyperthermia applicators facilitate well-controlled power deposition in tissues. In this paper, analysis of temperature elevation and experimental results in tissue phantom, animal tissue in vivo and animal tissue in vitro are presented for a waveguide applicator intended for treatment of brain tumors. It consisted of a G18 hypodermic needle attached via a conical velocity transformer to a 12.7-mm-diameter piezoelectric disk operated at 1.0 MHz. The axial acoustic pressure distribution had a standing-wave pattern with the four cycles/cm spatial periodicity. This periodicity was absent in the temperature distribution in tissue phantoms. The simulations based on a solution to the effective heat conductivity equation indicated that the hyperthermic range can be reached within a 4- and a 10-mm radius around the applicator for a 21- and a 60-mm sample diameters, respectively, with reasonable input power. The first number corresponded closely to the 5-mm radius observed in porcine brain in vivo and the second one came close to the 9-mm radius in porcine brain in vitro. The presented results demonstrate the potential of the ultrasound waveguide interstitial applicator for hyperthermia of small volume tumors.
小型圆柱形超声波源，用于通过体腔或间质植入物诱导高温。
DOI：
10.3109/02656739309022539
发表时间：
1993
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
Hynynen,K;Davis,KL
通讯作者：
Davis,KL
经直肠超声热疗治疗局部晚期前列腺腺癌的可行性和毒性。
DOI：
10.1016/0360-3016(93)90205-a
发表时间：
1993
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Fosmire,H;Hynynen,K;Drach,GW;Stea,B;Swift,P;Cassady,JR
通讯作者：
Cassady,JR