Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients
Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients
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2009 H1N1 流感灭活疫苗对儿童肝移植受者的免疫原性
DOI：
10.1016/j.vaccine.2011.04.012
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发表时间：
2011
期刊：
影响因子：
5.5
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Torii;Y. Kimura;H. Ochi;N. Kaneko;K. Ando;H. Kiuchi;T. Ito;Y.
为了评估 2009 H1N1 流感疫苗接种的安全性和免疫原性，根据日本指南，13 名儿童肝移植受者和 31 名免疫功能正常的对照者接种了不含佐剂的灭活流感疫苗。在参与者中没有观察到严重的不良事件和急性同种异体移植排斥反应。接受者的血清保护率（血凝素抑制 (HI) 抗体滴度≥1:40）为 53.8%，对照组为 58.1%（p=0.797）。接受组的血清转化率（HI 抗体升高 4 倍或更多）为 46.2%，对照组为 51.6% (p= 0.741)。两组疫苗接种后几何平均滴度均升高。与接种季节性流感疫苗相比，2009 H1N1 流感的血清转化率似乎高于季节性流感抗原，且接种后 2009 H1N1 流感的血清保护率明显提高。这些发现表明，儿科肝移植患者可能以与免疫功能正常的儿童类似的方式对灭活 2009 H1N1 流感疫苗产生安全反应。
To assess the safety and immunogenicity of 2009 H1N1 influenza vaccination, 13 pediatric liver transplant recipients and 31 immunocompetent controls received inactivated influenza vaccine without adjuvant according to Japanese guidelines. Serious adverse events and acute allograft rejections were not observed in participants. Seroprotection rates (hemagglutinin-inhibition (HI) antibody titer ≥ 1:40) were 53.8% among recipients and 58.1% among controls (p= 0.797). Seroconversion rates (4-fold or more HI antibody rise) were 46.2% for the recipient group and 51.6% for the control group (p= 0.741). Geometric mean titers were elevated after vaccination in both groups. In comparison with the seasonal influenza vaccination, the seroconversion rate for 2009 H1N1 appeared to be higher than that for seasonal influenza antigens, and the seroprotection rate for 2009 H1N1 clearly increased after vaccination. These findings suggest that pediatric liver transplant patients may respond safely to inactivated 2009 H1N1 influenza vaccines in a manner similar to immunocompetent children.