Fructose consumption as a risk factor for non-alcoholic fatty liver disease
Fructose consumption as a risk factor for non-alcoholic fatty liver disease
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DOI：
10.1016/j.jhep.2008.02.011
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发表时间：
2008-06-01
影响因子：
25.7
通讯作者：
Abdelmalek, Manal F.
中科院分区：
文献类型：
--
作者：
Ouyang, Xiaosen;Cirillo, Pietro;Abdelmalek, Manal F.
背景/目的：虽然非酒精性脂肪性肝病（NAFLD）的增加与肥胖和糖尿病的增加平行，但工业化国家的膳食果糖摄入量也显著增加。高果糖玉米糖浆的消费增加，主要以软饮料的形式，与胰岛素抵抗综合征的并发症有关。此外，果糖的肝脏代谢有利于从头脂肪生成和ATP消耗。我们假设果糖摄入量的增加有助于NAFLD的发展。方法：从活检证实的无肝硬化NAFLD患者（n = 49）和对照组（n = 24）中获得饮食史和配对血清和肝脏组织，这些患者的性别、年龄（5岁）和体重指数（3分）相匹配。结果：NAFLD患者的果糖消耗量比对照组高出近2- 3倍[365 kcal vs 170 kcal (p < 0.05)]。NAFLD患者（n = 6）肝脏果糖代谢重要酶果糖激酶（KHK）和脂肪生成重要酶脂肪酸合成酶mRNA表达升高（P = 0.04和P = 0.02）。在AML肝细胞系中，果糖导致KHK蛋白和活性的剂量依赖性增加。结论：NAFLD的发病机制可能与饮食中果糖摄入过多有关。(c) 2008欧洲肝脏研究协会。Elsevier B.V.版权所有。
Background/Aims: While the rise in non-alcoholic fatty liver disease (NAFLD) parallels the increase in obesity and diabetes, a significant increase in dietary fructose consumption in industrialized countries has also occurred. The increased consumption of high fructose corn syrup, primarily in the form of soft drinks, is linked with complications of the insulin resistance syndrome. Furthermore, the hepatic metabolism of fructose favors de novo lipogenesis and ATP depletion. We hypothesize that increased fructose consumption contributes to the development of NAFLD.Methods: A dietary history and paired serum and liver tissue were obtained from patients with evidence of biopsy-proven NAFLD (n = 49) without cirrhosis and controls (n = 24) matched for gender, age (5 years), and body mass index (3 points).Results: Consumption of fructose in patients with NAFLD was nearly 2- to 3-fold higher than controls [365 kcal vs 170 kcal (p < 0.05)]. In patients with NAFLD (n = 6), hepatic mRNA expression of fructokinase (KHK), an important enzyme for fructose metabolism, and fatty acid synthase, an important enzyme for lipogenesis were increased (P = 0.04 and p = 0.02, respectively). In an AML hepatocyte cell line, fructose resulted in dose-dependent increase in KHK protein and activity.Conclusions:The pathogenic mechanism underlying the development of NAFLD may be associated with excessive dietary fructose consumption. (c) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.