Liver iron concentration evaluated by two magnetic methods: Magnetic resonance imaging and magnetic susceptometry
Liver iron concentration evaluated by two magnetic methods: Magnetic resonance imaging and magnetic susceptometry
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DOI：
10.1002/mrm.20510
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发表时间：
2005-07-01
影响因子：
3.3
通讯作者：
Baffa, O
中科院分区：
文献类型：
--
作者：
Carneiro, AAO;Fernandes, JP;Baffa, O
肝脏铁浓度（LIC）的定量是至关重要的，在管理患者患有某些病理，可产生铁过载，如库利氏贫血和血色素沉着症。所有这些患者都必须控制其器官中的铁沉积水平，以避免高LIC的毒性，这可能是致命的。本文介绍了实验方案LIC测量使用两种磁技术：磁共振成像（MRI）和生物磁肝电阻（BLS）。MRI质子横向弛豫率（R-2）和图像强度，逐像素评估，被用作组织中铁负荷的指标。使用交流超导磁强计系统进行BLS LIC测量。一组23例患者的大范围的铁过载（0.9至34.5 mgFe/g（干）（组织））进行了评价与两种技术（MRI x BLS）。MRI和BLS测量的LIC值呈显著线性相关（r = 0.89 ~ 0.95）。这些结果表明，使用两种无创方法来评估肝脏铁储备在大浓度范围内的可行性，两种方法具有相当的精度。(c)2005 Wiley-Liss，Inc.
Quantification of liver iron concentration (LIC) is crucial in the management of patients suffering from certain pathologies that can produce iron overload, such as Cooley's anemia and hemo-chromatosis. All of these patients must control the level of iron deposits in their organs to avoid the toxicity of high LIC, which is potentially lethal. This paper describes experimental protocols for LIC measurement using two magnetic techniques: magnetic resonance imaging (MRI) and biomagnetic liver susceptometry (BLS). MRI proton transverse relaxation rate (R-2) and image intensity, evaluated pixel by pixel, were used as indicators of iron load in the tissue. LIC measurement by BLS was performed using an AC superconducting susceptometer system. A group of 23 patients with a large range of iron overload (0.9 to 34.5 mgFe/g(dry) (tissue)) was evaluated with both techniques (MRI x BLS). A significant linear correlation (r = 0.89 - 0.95) was found between the LIC by MRI and by BLS. These results show the feasibility of using two noninvasive methodologies to evaluate liver iron store in a large concentration range, Both methodologies represent an equivalent precision. (c) 2005 Wiley-Liss, Inc.