Studies of anti-F(ab')2 antibodies and possible immunologic control mechanisms in systemic lupus erythematosus.
Studies of anti-F(ab')2 antibodies and possible immunologic control mechanisms in systemic lupus erythematosus.
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DOI：
10.1002/art.1780271209
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发表时间：
1984-12
影响因子：
--
通讯作者：
F. Silvestris;A. Bankhurst;R. Searles;R. Williams
中科院分区：
文献类型：
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作者：
F. Silvestris;A. Bankhurst;R. Searles;R. Williams
应用酶联免疫吸附试验（ELISA）检测了51例系统性红斑狼疮（SLE）患者血清中抗DNA和抗F（ab '）2抗体。患有严重、未控制疾病的患者显示高水平的抗DNA和低水平的抗F（ab '）2抗体。静止期SLE患者常表现出高水平的抗F（ab '）2和低水平的抗DNA抗体。从自体SLE缓解血清或从SLE患者的未受影响的同胞的血清中分离的抗F（ab '）2抗体在使用与单链DNA反应的亲和纯化的SLE抗DNA抗体的测试系统中显示最大抑制。
Studies of anti-DNA and anti-F(ab')2 antibodies were performed by enzyme-linked immunosorbent assay in 51 patients with systemic lupus erythematosus (SLE). Patients with severe, uncontrolled disease showed high levels of anti-DNA and low levels of anti-F(ab')2 antibodies. Patients with quiescent SLE usually showed high levels of anti-F(ab')2 and low levels of anti-DNA antibodies. Isolated anti-F(ab')2 antibodies from autologous SLE remission serum or from the sera of unaffected siblings of SLE patients showed maximum inhibition in test systems using affinity-purified SLE anti-DNA antibodies reacting with single-stranded DNA.