The effect of template choice on morphometric analysis of pediatric brain data
The effect of template choice on morphometric analysis of pediatric brain data
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DOI：
10.1016/j.neuroimage.2008.12.046
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发表时间：
2009-04-15
期刊：
影响因子：
5.7
通讯作者：
Evans, Alan C.
中科院分区：
文献类型：
--
作者：
Yoon, Uicheul;Fonov, Vladimir S.;Evans, Alan C.
本研究探讨了“模板效应”的形态学分析的儿科脑MRI数据库获得8岁的儿童通过各种措施的表面和体积形态。我们首先从一组独立的儿科脑图像中构建了一个适合年龄的模板，然后将其与一个众所周知的成人脑模板ICBM 152进行了比较，这些模板来自我们的儿科数据库。根据儿科模板获得的个体皮质表面平均显示出明显更薄的皮质（-1.66 +/-1.60%，t=-15.18），皮质表面积较大（0.31 ± 0.70%，t=6.52），皮质折叠程度更高（0.08 ± 0.13%，t=8.72）。我们还发现基于成人模板的脑的脑脊液体积（-2.63 +/-4.84）和基于儿童模板的脑的皮质灰质（GM）体积（6.10 +/-7.81）显著增加。基于儿童模板的个体脑数据的交叉相关性（0.95，无脑掩模）显著高于基于成人模板的交叉相关性（0.88），并且当使用儿童模板时，非线性空间归一化期间的变形量显著减少（皮质GM类中的平均变形幅度：1.71 mm vs. 2.23 mm，t=12.39）。此外，还生成了取自研究受试者自身的“内部”儿科模板，并与“外部”儿科模板进行比较以供参考。这两种小儿脑模板和相关组织概率图之间没有显著差异。结果表明，在解释基于成人参考数据的儿科影像学研究结果时，有必要谨慎。(C)2009 Elsevier Inc. All rights reserved.
The present study investigated the "template effect" on the morphometric analysis of a pediatric brain MRI database obtained from 8-year-old children through various measures of surface and volumetric morphologies. We first constructed an age-appropriate template from an independent set of pediatric brain images and then compared it with a well-known adult brain template, the ICBM152, in terms of the morphometric features that resulted from our pediatric database. The individual cortical surface acquired based on the pediatric template exhibited, on average, a significantly thinner cortex (-1.66 +/- 1.60%, t=-15.18), larger cortical surface areas (0.31 +/- 0.70%, t=6.52), and a higher degree of cortical folding (0.08 +/- 0.13%, t=8.72) while compared with those based on the adult template. We also found a significant increase in the cerebrospinal fluid volume (-2.63 +/- 4.84) for the adult template based brains and the cortical gray matter (GM) volume (6.10 +/- 7.81) for the pediatric template based brains. The cross-correlation of pediatric template based individual brain data (0.95 without brain mask) was significantly higher than those of adult template based (0.88) and the amount of deformation during non-linear spatial normalization was significantly reduced when using the pediatric template (average magnitude of deformation in the cortical GM class: 1.71 mm vs. 2.23 mm, t=12.39). In addition, an "internal" pediatric template, taken from the study subjects themselves, was generated and compared with the "external" pediatric template for reference. There was no significant difference between these two pediatric brain templates and associated tissue probability maps. The results show that it is necessary to be cautious when interpreting results from pediatric imaging studies based on adult reference data. (C) 2009 Elsevier Inc. All rights reserved.