The proteasome: overview of structure and functions.

The proteasome: overview of structure and functions.
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蛋白酶体:结构和功能的概述。

DOI:
10.2183/pjab.85.12
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发表时间:
2009
期刊:
Proceedings of the Japan Academy. Series B, Physical and biological sciences
影响因子:
--
通讯作者:
Tanaka K
Tanaka K
中科院分区:
其他
文献类型:
--
作者:
Tanaka K

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蛋白酶体是一种高度复杂的酶复合体,旨在对客户蛋白进行选择性、高效和过程性的水解。已知它与泛素合作,泛素聚合形成真核细胞中受调控的蛋白分解的标记。高度组织化的蛋白酶体通过快速和单向地催化生物反应,在控制一系列不同的基本细胞活动方面发挥着重要作用。在过去的四分之一个世纪里,对蛋白酶体的研究为我们提供了对其结构和功能的深刻见解,这对我们理解细胞生命有相当大的贡献。然而,许多问题仍有待澄清。
The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to form a marker for regulated proteolysis in eukaryotic cells. The highly organized proteasome plays a prominent role in the control of a diverse array of basic cellular activities by rapidly and unidirectionally catalyzing biological reactions. Studies of the proteasome during the past quarter of a century have provided profound insights into its structure and functions, which has appreciably contributed to our understanding of cellular life. Many questions, however, remain to be elucidated.
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