Interaction between physical activity, PITX1 rs647161 genetic polymorphism and colorectal cancer risk in a Korean population: a case-control study.
Interaction between physical activity, PITX1 rs647161 genetic polymorphism and colorectal cancer risk in a Korean population: a case-control study.
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DOI：
10.18632/oncotarget.24136
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发表时间：
2018-01-26
期刊：
影响因子：
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通讯作者：
Kim, Jeongseon
中科院分区：
文献类型：
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作者：
Gunathilake, Madhawa Neranjan;Lee, Jeonghee;Kim, Jeongseon
本研究基于韩国人PITX 1基因多态性评估了体力活动与结直肠癌（CRC）风险之间的相互作用。总共有923例病例和1，846例对照在韩国国家癌症中心入组。经常锻炼的受试者发生CRC的风险显著低于不经常锻炼的受试者（OR = 0.37，95%CI = 0.30-0.45）。处于每周任务代谢当量（MET）-分钟最高三分位数的受试者显示CRC风险显著降低（OR = 0.62，95%CI = 0.48-0.79，p趋势< 0.001）。在显性模型中，次要等位基因携带者比主要等位基因纯合子受试者显示出显著更高的CRC风险（OR = 1.46，95%CI = 1.18-1.80）。在所有受试者中，PITX 1遗传变异与定期运动和CRC风险（p-相互作用= 0.018）和结肠癌风险（p-相互作用= 0.029）之间存在显著的相互作用。携带至少一个次要等位基因且不经常锻炼的受试者显示出更高的CRC风险（OR = 1.81，95%CI = 1.37-2.41）。主要等位基因纯合子且体力活动量高的受试者显示CRC风险显著降低（OR = 0.56，95%CI = 0.38-0.82）。因此，具有PITX 1遗传变异的个体可以从韩国人群中预防CRC风险的体力活动中获益。
This study assessed the interaction between physical activity and colorectal cancer (CRC) risk based on a polymorphism in the paired-like homeodomain 1 (PITX1) gene in Koreans. In total, 923 cases and 1,846 controls were enrolled at the National Cancer Center, Korea. Subjects who did regular exercise showed a significantly reduced risk of CRC than those did not exercise regularly (OR = 0.37, 95% CI = 0.30-0.45). Subjects in the highest tertile of metabolic equivalents of task (MET)-minutes per week showed a significantly lower risk of CRC (OR = 0.62, 95% CI = 0.48-0.79, p-trend < 0.001). In the dominant model, minor allele carriers showed a significantly higher risk of CRC than subjects homozygous for the major allele (OR = 1.46, 95% CI = 1.18-1.80). The PITX1 genetic variant showed significant interactions with regular exercise and CRC risk (p-interaction = 0.018) and colon cancer risk (p-interaction = 0.029) among all subjects. Subjects who carried at least one minor allele and did not regularly exercise showed a greater risk of CRC (OR = 1.81, 95% CI = 1.37-2.41). Subjects who were homozygous for the major allele with high physical activity showed a significantly reduced risk of CRC (OR = 0.56, 95% CI = 0.38-0.82). Thus, individuals with PITX1 genetic variants can have benefit from physical activity regarding prevention of CRC risk in a Korean population.