Association of Genetic Polymorphisms at 8q24 With the Risk of Prostate Cancer in a Japanese Population
Association of Genetic Polymorphisms at 8q24 With the Risk of Prostate Cancer in a Japanese Population
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DOI：
10.1002/pros.20831
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发表时间：
2008-11-01
期刊：
影响因子：
2.8
通讯作者：
Ogawa, Osamu
中科院分区：
文献类型：
--
作者：
Terada, Naoki;Tsuchiya, Norihiko;Ogawa, Osamu
背景资料。遗传因素，以及环境因素的组合，都会导致前列腺癌(PC)的风险。最近，全基因组连锁研究发现了染色体8q24上与PC密切相关的几个独立的单核苷酸多态(SNPs)。方法我们分析了其中两个SNPs，rs1447295和rs6983267，以检查与日本男性PC风险的关系。结果rs1447295A等位基因与前列腺癌的易感性相关(PC与非PC：P=0.041；OR1.28；95%CI=1.01~1.61)，且与侵袭性PC的相关性更显著(侵袭性PC与正常对照组，P=0.013；OR1.43；95%CI=1.08~1.90)。Rs6983267G等位基因与PC易感性无关(PC与非PC：P=0.967；OR=1.00；95%CI=0.83~1.21)。然而，在非侵袭性PC中，它与疾病相关(非侵袭性PC与正常对照组：P=0.0068；OR，1.43；95%CI=1.1-1.85)。结论：位于8q24的这两个SNP与前列腺癌的风险增加有关，并与日本男性的肿瘤侵袭性有关。前列腺68：1689-1695,2008，(C)2008 Wiley-Liss，Inc.
BACKGROUND. Genetic factors, as well as a combination of environmental factors, contribute to the risk of prostate cancer (PC). Recently, genome-wide linkage studies found several independent single nucleotide polymorphisms (SNPs) that are strongly associated with PC on chromosome 8q24.METHODS. We analyzed two of these SNPs, rs1447295 and rs6983267, to examine association with the risk of PC in Japanese men. These SNPs were examined by a mismatch PCR-RFLP method in 507 PC patients (286 aggressive and 221 non-aggressive) and in 511 non-PC patients (124 benign prostatic hyperplasia and 387 normal male controls) and the allele frequencies were then compared between groups.RESULTS. The rs1447295 A allele was associated with susceptibility to PC (PC vs. non-PC: P = 0.041; OR, 1.28; 95%CI = 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, P = 0.013; OR, 1.43; 95%CI = 1.08-1.90). The rs6983267 G allele did not show significant association with susceptibility to PC (PC vs. non-PC: P = 0.967; OR, 1.00; 95%CI = 0.83-1.21). However, it was associated with disease in non-aggressive PC (non-aggressive PC vs. normal controls: P = 0.0068; OR, 1.43; 95%CI = 1.10-1.85).CONCLUSIONS. The two SNPs at 8q24 were associated with an increased risk of prostate cancer and contributed to tumor aggression in Japanese men. Prostate 68: 1689-1695, 2008, (C) 2008 Wiley-Liss, Inc.