Hypersomnolence and increased REM sleep with low cerebrospinal fluid hypocretin level in a patient after removal of craniopharyngioma
Hypersomnolence and increased REM sleep with low cerebrospinal fluid hypocretin level in a patient after removal of craniopharyngioma
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DOI：
10.1016/j.sleep.2005.04.002
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发表时间：
2005-11-01
期刊：
影响因子：
4.8
通讯作者：
Nishino, S
中科院分区：
文献类型：
--
作者：
Tachibana, N;Taniike, M;Nishino, S
我们报告一位女孩在颅咽管瘤切除后，出现嗜睡，并有广泛的下丘脑损害。短睡眠潜伏期、多次睡眠潜伏期试验（MREM）中的睡眠开始REM期和阴性HLA DQB 1 *0602分型提示诊断为症状性发作性睡病。脑脊液下丘脑泌素-1水平低表明下丘脑中产生下丘脑泌素的神经元被破坏。整夜多导睡眠图记录的快速眼动睡眠量增加和快速眼动睡眠周期性缺乏与之前关于下丘脑分泌素缺乏的特发性症状性发作性睡病的报告不同。手术后脑部磁共振成像（MRI）显示下丘脑更全面的病变似乎导致该患者REM睡眠明显解除抑制以及嗜睡。(c)2005 Elsevier B. V.保留所有权利。
Here we report a hypersomnolent girl with extensive hypothalamic damage after removal of a craniopharyngioma. The presence of a short sleep latency, sleep onset REM periods during a multiple sleep latency test (MSLT) and negative HLA DQB1*0602 typing suggested a diagnosis of symptomatic narcolepsy. Low cerebrospinal fluid hypocretin-1 level indicated destruction of hypocretin-producing neurons in the hypothalamus. An increased amount of REM sleep and a lack of REM sleep cyclicity documented by all-night polysomnography were different findings from previous reports of hypocretin-deficient idiopathic symptomatic narcolepsy. A more global hypothalamic lesion demonstrated by brain magnetic resonance imaging (MRI) after surgery seemed to cause marked disinhibition of REM sleep as well as hypersomnolence in this patient. (c) 2005 Elsevier B.V. All rights reserved.