The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice.
The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice.
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DOI：
10.1371/journal.pone.0162183
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Seishima M
中科院分区：
文献类型：
--
作者：
Ogiso H;Ito H;Ando T;Arioka Y;Kanbe A;Ando K;Ishikawa T;Saito K;Hara A;Moriwaki H;Shimizu M;Seishima M
在本研究中，我们研究了吲哚胺2，3-双加氧酶(IDO)在CCl4诱导的肝纤维化发展中的作用。与WT小鼠相比，IDO-KO小鼠重复给予CCl4所致的肝纤维化加重。在用CCl4处理的IDO-KO小鼠中，肝脏中几种炎症细胞的数量和促炎细胞因子的表达增加。结果表明，与WT小鼠相比，IDO-KO小鼠重复注射CCl4后，活化的肝星状细胞(HSCs)和HSCs上的纤维化因子增加。此外，L色氨酸治疗可加重WT小鼠CCl_4诱导的肝纤维化。我们的研究结果表明，IDO缺乏增加了反复接受CCl4处理的小鼠肝脏的炎症，并加剧了肝纤维化。
In the present study, we examined the role of indoleamine 2,3-dioxygenase (IDO) in the development of CCl4-induced hepatic fibrosis. The liver fibrosis induced by repetitive administration with CCl4 was aggravated in IDO-KO mice compared to WT mice. In IDO-KO mice treated with CCl4, the number of several inflammatory cells and the expression of pro-inflammatory cytokines increased in the liver. In the results, activated hepatic stellate cells (HSCs) and fibrogenic factors on HSCs increased after repetitive CCl4 administration in IDO-KO mice compared to WT mice. Moreover, the treatment with l-tryptophan aggravated the CCl4-induced hepatic fibrosis in WT mice. Our findings demonstrated that the IDO deficiency enhanced the inflammation in the liver and aggravated liver fibrosis in repetitive CCl4-treated mice.
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影响因子：
2.7
作者：
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通讯作者：
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