[Study on heterotransplantation of malignant urogenital tumors in nude mice: results of transplantation and the characteristics of the explants].
[Study on heterotransplantation of malignant urogenital tumors in nude mice: results of transplantation and the characteristics of the explants].
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泌尿生殖系统恶性肿瘤裸鼠异种移植研究：移植结果及外植体特点
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
O. Yoshida
中科院分区：
文献类型：
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作者：
K. Okada;O. Yoshida
自1976年以来，我们在裸鼠身上移植了82例泌尿系统肿瘤，其中46例（56%）成功。其中35例（占肿瘤总数的43%）正在接受连续移植。这个成功率似乎比其他研究所获得的泌尿生殖系统肿瘤和其他组织来源的肿瘤都要高。即使经过长时间的异源移植，其组织形态和肿瘤标志物也基本保持了原肿瘤的原有特征。然而，一些肿瘤系的组织学特征似乎减少了。在反复移植过程中丢失了一定的细胞群。这种克隆选择可能是由于能够适应移植环境的细胞群的生长。然而，裸鼠异体移植实验是包括泌尿系统领域在内的各种癌症研究中最有价值的工具之一，因为相当高比例的泌尿系统恶性肿瘤在长时间内保持其原有特征。
Since 1976, we have transplanted 82 urological neoplasms into nude mice, 46 of which (56%) took. Thirty five of them (43% of the total tumors) are being serially transplanted. This rate of success seems to be better than that obtained at other institutes for both neoplasms of urogenital as well as other tissue origin. The explants basically retained the original characteristics of the native tumors not only in histological pattern but also in tumor markers, even after a long term period of heterotransplantation. However, the histological features of some tumor lines seemed to be reduced. A certain cell population was lost during repeated transplantations. Such a clonal selection may have resulted from the outgrowth of the cell population capable of adapting to the transplanted environment. Nevertheless heterotransplantation experiments in nude mice are one of the most valuable tools in various cancer research including that in the urological field since a rather high percentage of urologic malignancies take while retaining their original characteristics for a long time.