Dysregulated brain development in adult men with schizophrenia: A magnetic resonance imaging study
Dysregulated brain development in adult men with schizophrenia: A magnetic resonance imaging study
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DOI：
10.1016/s0006-3223(02)01835-8
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发表时间：
2003-03-01
影响因子：
10.6
通讯作者：
Mintz, J
中科院分区：
文献类型：
--
作者：
Bartzokis, G;Nuechterlein, KH;Mintz, J
背景：最近的影像学证据表明，正常的大脑发育/额叶和相关区域的成熟是一个受良好调节的过程，包括持续的髓鞘形成和白质体积的扩大，直到40多岁，同时伴有灰质体积的减少。这一过程的失调可能导致精神分裂症综合征的可能性使用磁共振成像进行了研究。方法：对52名正常成年男性和35名精神分裂症患者进行磁共振成像。冠状图像的获取使用脉冲序列最大化髓磷脂信号。灰质与白质比值的年龄相关变化被用来衡量精神分裂症受试者的发育失调，并与正常对照组的年龄相关变化进行对比。结果：额叶和颞叶灰质与白质比的回归分析显示，诊断与年龄在这两个区域之间的相互作用非常显著（p = 0.0003和p = 0.01）。在正常组中，额叶和颞叶灰质与白质之比在整个年龄范围内显著呈线性下降。相比之下，在精神分裂症组中，这两个比率都没有显示出有意义的年龄相关变化。因此，两组间灰质与白质比例的差异随着年龄的增长而显著增加，主要是由于患者组中没有白质体积扩张。结论：在精神分裂症样本中，灰质和白质中缺乏正常的随年龄增长的互补体积变化，表明这种动态发育过程在成年精神分裂症受试者中失调。髓鞘形成对大脑的持续成熟和正常功能的重要性对精神分裂症的诊断、治疗和预后具有重要意义。
Background: Recent imaging evidence suggests that normal brain development/maturation of the frontal lobes and association areas is a well-regulated process consisting of continued myelination and expansion of white matter volumes into the late 40s accompanied by complementary reductions in gray matter volumes. The possibility that a dysregulation of this process may contribute to the syndrome of schizophrenia was investigated using magnetic resonance imaging.Methods: Fifty-two normal adult males and 35 males with schizophrenia underwent magnetic resonance imaging. Coronal images were acquired using pulse sequences that maximized myelin signal. The age-related change in the gray to white matter ratio was used as a measure of developmental dysregulation in the schizophrenic subjects and contrasted to the age-related changes of the normal control group.Results: Regression analyses on frontal and temporal gray to white matter ratio yielded highly significant interactions of diagnosis and age for both regions (p = .0003 and p =.01, respectively). In the normal group, both frontal and temporal gray to white matter ratios decreased significantly and linearly across the age range. In contrast, neither ratio showed meaningful age-related change in the schizophrenia group. Thus, differences in gray to white matter ratio between the groups increased markedly with age, driven primarily by the absence of a white matter volume expansion in the patient group.Conclusions: The absence of the normal complementary volume changes in the gray and white matter with age in the schizophrenic sample suggests that this dynamic developmental process is dysregulated in adult schizophrenic subjects. The importance of myelination to the continued maturation and normal functioning of the brain has implications for the diagnosis, treatment, and prognosis of schizophrenia.