INDEL polymorphisms at the DXS10146 flanking region in four racial populations
INDEL polymorphisms at the DXS10146 flanking region in four racial populations
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四个种族人群 DXS10146 侧翼区域的 INDEL 多态性
DOI：
10.1016/j.fsigss.2013.10.162
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发表时间：
2013
影响因子：
--
通讯作者：
Yasuo Bunai
中科院分区：
文献类型：
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作者：
Atsushi. Nagai;Masaaki Hara;Tomomi Ishihara;Akiyoshi Tamura;Akira Kido;Yasuo Bunai
对151名日本男性、60名印度尼西亚男性和90名南非男性（32名白人和58名非洲人）的X染色体STR DXS 10146 3′侧翼区插入/缺失（INDEL）多态性进行了分析。3′侧翼区17 bp INDEL多态性在所有人群中均存在。在非洲人群中，新发现的4-bp和7-bp的INDEL多态性的DXS 10146的核心重复单元的下游13 bp和25 bp，分别。在本研究中未观察到在这些INDEL处具有两个或三个缺失的样品。在这四个群体中，所有的缺失事件在INDEL区域中观察到的DXS 10146核心重复单位的可变（TTCC）重复块中的6个重复数多态性的等位基因。
Insertion/deletion (INDEL) polymorphisms in the 3′ flanking region of the X chromosomal STR DXS10146 were analysed in the following four racial populations: 151 Japanese males, 60 Indonesian males and 90 South African males (32 Caucasians and 58 Africans). A 17-bp INDEL polymorphism in the 3′ flanking region was observed in all populations. In the African population, 4-bp and 7-bp INDEL polymorphisms were newly found 13 bp and 25 bp downstream of the core repeat unit of DXS10146, respectively. No samples with two or three deletions at these INDELs were observed in this study. In these four populations, all deletion events at the INDEL regions were observed only in alleles with six repeat number polymorphisms in the variable (TTCC) repeat block of the DXS10146 core repeat unit.