Effects of chronic benzodiazepine exposure on stress-induced neuroactive steroid levels.
Effects of chronic benzodiazepine exposure on stress-induced neuroactive steroid levels.
复制标题
慢性苯二氮卓类药物暴露对应激诱导的神经活性类固醇水平的影响。
DOI：
10.1016/s0006-8993(99)01198-1
复制
发表时间：
1999
期刊：
影响因子：
2.9
通讯作者：
Frye,CA
中科院分区：
文献类型：
--
作者：
Wilson,MA;Frye,CA
Since the neuroactive steroid 3α,5α-tetrahydroprogesterone (3α,5α-THP) has pharmacologic actions similar to benzodiazepine agonists such as diazepam, the influences of chronic diazepam exposure on stress-induced brain levels of 3α,5α-THP were examined. Groups of male, female, orchidectomized (ORCH), and ovariectomized (OVX) rats were compared, along with OVX groups given hormone replacement. Chronic diazepam exposure diminished stress-induced brain levels of 3α,5α-THP and serum corticosterone, although gender, gonadectomy and hormone replacement had disparate influences on these two endocrine responses to stress.
