LAP+ Treg is a better biomarker than total Treg in viral myocarditis
LAP+ Treg is a better biomarker than total Treg in viral myocarditis
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DOI：
10.1002/jmv.25378
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发表时间：
2019-01
影响因子：
12.7
通讯作者：
Xinggang Wang;J. Ge;Ruizhen Chen
中科院分区：
文献类型：
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作者：
Xinggang Wang;J. Ge;Ruizhen Chen
潜伏相关肽（Latency associated peptide，LTP）是一种表达于调节性T细胞（regulatory T cells，Treg）膜上的蛋白质。Treg + Treg的免疫调节作用强于阴性Treg。在本研究中，我们提供了在病毒性心肌炎小鼠的CD4+细胞中的CD4 + Treg的比例的数据，我们认为这比CD4+细胞中的总Treg的比例更敏感和特异性。与以前公认的总Treg相比，Treg + Treg是一种更好的心肌炎症生物标志物。
Latency associated peptide (LAP) is a protein expressed on the membrane of some regulatory T cells (Treg). LAP+ Treg have a greater immunomodulatory effect than that of their negative counterparts. In this study, we presented the data on the proportion of LAP+ Treg out of CD4+ cells in mice with viral myocarditis, which we believed was more sensitive and specific than that of the ratio of total Treg in CD4+ cells. Comparing with the previously recognized total Treg, LAP+ Treg was a better biomarker on myocardial inflammation.