Do anabolic-androgenic steroids have performance-enhancing effects in female athletes?
Do anabolic-androgenic steroids have performance-enhancing effects in female athletes?
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DOI：
10.1016/j.mce.2017.07.010
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发表时间：
2018-03-15
影响因子：
4.1
通讯作者：
Basaria, Shehzad
中科院分区：
文献类型：
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作者：
Huang, Grace;Basaria, Shehzad
使用合成代谢雄激素类固醇（AAS）在男性和女性运动员中很常见，并且是一个日益严重的公共卫生问题。对德意志民主共和国在优秀女运动员中实施的系统性国家赞助的兴奋剂计划的历史数据以及非运动员女性中睾酮管理的临床试验的回顾表明，MS对女性具有致能作用。在女运动员中使用AAS与不良反应有关，包括痤疮、多毛症、声音加深和月经紊乱;也有报告称会出现危及生命的不良反应，如心律失常和猝死。因此，检测AAS滥用的女运动员是很重要的，以确保公平的竞争，同时，运动员应了解AAS使用的不良后果。尽管外源性雄激素的给药与致能作用相关，但仍不清楚在某些医学疾病中观察到的内源性高雄激素血症，如性发育障碍（DSD），先天性肾上腺皮质增生和多囊卵巢综合征，是否赋予任何竞争优势。需要精心设计的研究来确定内源性高雄激素血症对女运动员运动成绩的影响。(C)2017爱思唯尔B. V.保留所有权利。
Doping with anabolic-androgenic steroids (AAS) is common among both male and female athletes and is a growing public health problem. Review of historical data of systematic state-sponsored doping programs implemented by the German Democratic Republic in elite female athletes and from clinical trials of testosterone administration in non-athlete women suggests that MS have ergogenic effects in women. The use of AAS in female athletes has been associated with adverse effects that include acne, hirsutism, deepening of the voice and menstrual disturbances; life-threatening adverse effects such as cardiac arrhythmias and sudden death have also been reported. Therefore, detection of AAS abuse in female athletes is important to ensure fairness in competition; at the same time, the athletes should be educated regarding the adverse consequences of AAS use. Although administration of exogenous androgens have been associated with ergogenic effects, it remains unclear whether endogenous hyperandrogenism seen in some medical conditions such as disorders of sexual development (DSD), congenital adrenal hyperplasia and polycystic ovary syndrome, confers any competitive advantage. Well-designed studies are needed to determine the effects of endogenous hyperandrogeriism on athletic performance in female athletes. (C) 2017 Elsevier B.V. All rights reserved.