Chromatin landscape Methylation beyond transcription
Chromatin landscape Methylation beyond transcription
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DOI：
10.4161/epi.6.1.13331
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发表时间：
2011-01-01
期刊：
影响因子：
3.7
通讯作者：
Whetstine, Johnathan R.
中科院分区：
文献类型：
--
作者：
Black, Joshua C.;Whetstine, Johnathan R.
细胞核被组织和划分成一个高度有序的结构，包含DNA、RNA、染色体和组蛋白。与这些不同成分相关的动力学负责确保DNA的正确复制，基因的正确转录和基因组的稳定。毫不奇怪，这些不同成分的改变与癌症等病理直接相关。这一观点侧重于染色质修饰景观，特别是组蛋白3赖氨酸9甲基化（H3K9me）和异染色质蛋白（HP1）在调节dna模板化过程中的作用，特别关注它们在非基因区域的作用和对染色质结构的影响。这些观察结果将进一步扩展到染色质景观的改变将有助于疾病的作用。这种观点强调组蛋白修饰景观的改变不仅与转录有关，而且在染色质结构、核结构、细胞周期、基因组稳定性和疾病进展方面具有广泛的影响。
The nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins. The dynamics associated with these various components are responsible for making sure that the DNA is properly duplicated, genes are properly transcribed and the genome is stabilized. It is no surprise that alterations in these various components are directly associated with pathologies like cancer. This Point-of-View focuses on the role the chromatin modification landscape, especially histone 3 lysine 9 methylation (H3K9me) and heterochromatin proteins (HP1) play in regulating DNA-templated processes, with a particular focus on their role at non-genic regions and effects on chromatin structure. These observations will be further extended to the role that alterations in chromatin landscape will contribute to diseases. This Point-of-View emphasizes that alterations in histone modification landscapes are not only relevant to transcription but have broad range implications in chromatin structure, nuclear architecture, cell cycle, genome stability and disease progression.