Cadherin-catenin proteins in vertebrate development
Cadherin-catenin proteins in vertebrate development
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DOI：
10.1016/j.ceb.2006.07.001
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发表时间：
2006-10-01
影响因子：
7.5
通讯作者：
Vasioukhin, Valeri
中科院分区：
文献类型：
--
作者：
Lien, Wen-Hui;Klezovitch, Olga;Vasioukhin, Valeri
钙粘蛋白-连环蛋白粘附是多细胞生物发育的关键。大量的同型相互作用钙粘蛋白、快速组装和拆卸以及与产生力的肌动蛋白细胞骨架的连接等特征使钙粘蛋白介导的连接成为细胞和组织在发育过程中执行复杂变化的理想结构。最近的研究结果强调了钙粘蛋白-连环蛋白在主要发育途径中的关键调节作用。我们重新评估了钙粘蛋白-连环蛋白粘附结构的重要性，并提出除了细胞间粘附外，它们还可以作为细胞外部环境的生物传感器，帮助调节单个细胞的行为，以确保整个生物体的生存。
Cadherin-catenin adhesion is pivotal for the development of multicellular organisms. Features such as a large repertoire of homotypically interacting cadherins, rapid assembly and disassembly, and a connection to a force-generating actin cytoskeleton make cadherin-mediated junctions ideal structures for the execution of complex changes in cell and tissue morphology during development. Recent findings highlight the role of cadherin-catenin proteins as critical regulators of major developmental pathways. We re-evaluate the significance of cadherin-catenin adhesion structures and propose that in addition to intercellular adhesion, they may be used as biosensors of the external cellular environment that help adjust the behavior of individual cells to ensure survival of the entire organism.