Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-κB without affecting IκB degradation
Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-κB without affecting IκB degradation
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DOI：
10.1016/j.febslet.2004.06.056
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发表时间：
2004-07-30
期刊：
影响因子：
3.5
通讯作者：
Kim, Y
中科院分区：
文献类型：
--
作者：
Shin, HM;Kim, MH;Kim, Y
4-甲基- n '-（3-苯基-丙基）-苯-1,2-二胺（JSH-23）是一种新的化学合成化合物。芳香族二胺JSH-23化合物对脂多糖（LPS）刺激的巨噬细胞核因子(NF)- κ b转录活性有抑制作用，IC50值为7.1 muM；RAW 264.7，干扰lps诱导的NF-kappaB核易位，但不影响IkappaB降解。这种作用机制在控制NF-kappaB激活方面是非常罕见的。此外，该化合物不仅能抑制lps诱导的肿瘤坏死因子- α、白细胞介素-1 β、IL-6、诱导型一氧化氮合酶和环氧化酶-2的表达，还能抑制lps诱导的RAW 264.7细胞凋亡。(C) 2004年欧洲生化学会联合会。Elsevier B.V.版权所有。
4-Methyl-N'-(3-phenyl-propyl)-benzene-1,2-diamine (JSH-23) is a novel chemically synthetic compound. The aromatic diamine JSH-23 compound exhibited inhibitory effect with an IC50 value of 7.1 muM on nuclear factor (NF)-kappaB transcriptional activity in lipopolysaccharide (LPS)-stimulated macrophages; RAW 264.7, and interfered LPS-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. This mechanism of action is very rare for controlling NF-kappaB activation. Furthermore, the compound inhibited not only LPS-induced expressions of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.