CEREBRO‐HEPATO‐RENAL SYNDROME. REPORT OF A CASE WITH HISTOCHEMICAL AND ULTRASTRUCTURAL OBSERVATIONS
CEREBRO‐HEPATO‐RENAL SYNDROME. REPORT OF A CASE WITH HISTOCHEMICAL AND ULTRASTRUCTURAL OBSERVATIONS
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脑肝肾综合征一例的组织化学和超微结构观察报告
DOI：
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发表时间：
1976
影响因子：
3.2
通讯作者：
G. D. Timmons
中科院分区：
文献类型：
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作者：
Dimistri P. Agamanolis;H. Robinson;G. D. Timmons
报告了一例新的脑肝肾综合征。神经病理改变包括大脑、小脑皮层和下橄榄发育异常。此外，中枢神经系统有代谢变化，表现为组织细胞内脂质积累或灰质和白质中游离脂质，白质髓鞘形成和胶质形成不足，灰质中原生质星形胶质细胞明显增殖。该病例的一个独特特征是小脑分子层中存在大量充满脂质的巨噬细胞簇和偶尔出现的胆固醇晶体。脂质沉积的组织化学反应和超微结构表现提示有几种不同类型的脂质积聚。
A new case of the cerebro-hepato-renal syndrome is being reported. The neuropathologic changes consisted of developmental abnormalities of cere-bral and cerebellar cortex and of the inferior olives. In addition, there were metabolic changes in the central nervous system, indicated by an accumula-tion of lipid within histiocytes or free in gray and white matter, deficiency in myelination and gliesis of the white matter, and marked proliferation of protoplasmic astrocytes in the gray matter. A unique feature of this case was the presence of numerous clusters of lipid-filled macrophages and occasional cholesterol crystals in the molecular layer of the cerebellum. The histochemi-cal reactions and ultrastructural appearances of the lipid deposits are sugges-tive of accumulation of several different types of lipids.