Reperfusion-induced changes in capillary perfusion and filtration: effects of hypercholesterolemia.
Reperfusion-induced changes in capillary perfusion and filtration: effects of hypercholesterolemia.
复制标题
再灌注引起的毛细血管灌注和过滤变化：高胆固醇血症的影响。
DOI：
10.1152/ajpheart.1999.277.2.h669
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Harris,NR
中科院分区：
文献类型：
--
作者：
Harris,NR
Fluid filtration rate (Jv/S) and red blood cell velocity (VRBC) in individual mesenteric capillaries of normocholesterolemic (NC) and hypercholesterolemic (HC) rats were measured before and after ischemia and reperfusion (I/R). In NC rats, a correlation was found between baselineJv/Sand the percent of the feeding arteriole length that was paired (<15 μm) with a postcapillary venule (A-V pairing), but not in the HC group. Additionally, in NC rats only, a correlation was found between baselineVRBCand A-V pairing. In capillaries in which A-V pairing was substantial (>20%),VRBCdropped after reperfusion in the HC group (54% of baseline;P< 0.05), but not in the NC group (79%). The decrease inVRBCin HC rats could be attenuated by a P-selectin antibody (PB1.3). PB1.3 was also able to attenuate the increase in I/R-induced capillaryJv/Sin HC rats (median increase = 1.26-fold vs. 1.53-fold without PB1.3). These data suggest a role for A-V pairing in capillary perfusion in NC rats and a potential role for P-selectin in I/R-induced microvascular dysfunction in HC rats.
