B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.
B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.
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脾脏中的B细胞发育发生在离散的步骤中，并取决于B细胞受体衍生的信号的质量。
DOI：
10.1084/jem.190.1.75
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发表时间：
1999-07-05
影响因子：
15.3
通讯作者：
Carsetti, R
中科院分区：
文献类型：
--
作者：
Loder, F;Mutschler, B;Ray, R J;Paige, C J;Sideras, P;Torres, R;Lamers, M C;Carsetti, R
只有成熟的B淋巴细胞才能进入脾脏和淋巴结的淋巴滤泡，从而有效地参与免疫反应。成熟的、长寿命的B淋巴细胞来源于骨髓中产生的短寿命前体细胞。我们发现，被选入成熟细胞群是一个主动过程，且发生在脾脏中。脾脏中的两类B细胞群被确定为成熟B细胞的前体细胞。1型过渡性B细胞（T1）是近期从骨髓迁移而来的。它们发育为2型过渡性B细胞（T2），2型过渡性B细胞处于细胞周期中，且仅存在于脾脏的初级滤泡中。成熟的B细胞可由T1或T2 B细胞产生。
Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-lived precursors generated in the bone marrow. We show that selection into the mature pool is an active process and takes place in the spleen. Two populations of splenic B cells were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 (T2), which are cycling and found exclusively in the primary follicles of the spleen. Mature B cells can be generated from T1 or T2 B cells.