Prolonged survival in carcinomatous meningitis associated with breast cancer.
Prolonged survival in carcinomatous meningitis associated with breast cancer.
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与乳腺癌相关的癌性脑膜炎的生存期延长。
DOI：
10.1097/00007611-199503000-00023
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
S. Vandenberg
中科院分区：
文献类型：
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作者：
P. Moots;M. Harrison;S. Vandenberg
我们描述了一个病人谁生存超过7年后诊断脑膜癌病与乳腺癌。脑膜癌病发生在1%至5%的乳腺癌患者中。中位生存期为3至7个月，但大多数报告包括少数存活时间更长的患者，高达11%的患者存活超过1年。早期诊断、积极治疗神经系统受累、有限的全身肿瘤负荷和不同的进展率是可能与这些乳腺癌患者生存期延长相关的因素。我们的病人是一个对肿瘤有反应的乳腺腺癌，没有全身转移，说明脑膜癌病，像其他形式的乳腺癌转移一样，可以进行一个无痛的过程。在这样的患者中，治疗转移到中枢神经系统的延迟后遗症可以深刻地影响疾病的进程。
We describe a patient who survived for more than 7 years after the diagnosis of meningeal carcinomatosis associated with breast cancer. Meningeal carcinomatosis occurs in 1% to 5% of patients with breast cancer. The median survival ranges from 3 to 7 months, but most reports include a small number of patients who survive considerably longer, with up to 11% surviving more than 1 year. Early diagnosis, aggressive treatment of neurologic involvement, limited systemic tumor burden, and varied rates of progression are factors that may relate to extended duration of survival in these patients with breast cancer. Our patient, with a hormonally responsive adenocarcinoma of the breast and without systemic metastases, illustrates that meningeal carcinomatosis, like other forms of breast cancer metastasis, can run an indolent course. In such patients the delayed sequelae of therapy for metastasis to the central nervous system can profoundly influence the course of the illness.