Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study
Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study
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DOI：
10.1016/j.canlet.2006.04.001
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发表时间：
2007-03-08
期刊：
影响因子：
9.7
通讯作者：
Raaschou-Nielsen, Ole
中科院分区：
文献类型：
--
作者：
Vogel, Ulla;Sorensen, Mette;Raaschou-Nielsen, Ole
由ERCC1 Asn118Asn(A)，ASE-1 G-21A(G)，RAI IVS1 A4364G(A)组成的单倍型纯合子携带者患肺癌的风险增加，特别是在女性中。在一个病例队列研究中，我们分析了基因-环境与预定义单倍型的交互作用，其中包括428例肺癌病例和800人的对照组，所有这些人都来自57,000名丹麦的前瞻性饮食、癌症和健康队列。在高吸烟强度(>；20克烟草/天)下，只有单倍型纯合携带者的女性中吸烟强度的额外风险(IRR=2.03；95%可信区间：每天每增加5克烟草1.10-3.73。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women.Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes.At high smoking intensity (> 20 g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10-3.73 per 5 additional g tobacco/day). (c) 2006 Elsevier Ireland Ltd. All rights reserved.