INCREASED LIFE-SPAN OF AGE-1 MUTANTS IN CAENORHABDITIS-ELEGANS AND LOWER GOMPERTZ RATE OF AGING
INCREASED LIFE-SPAN OF AGE-1 MUTANTS IN CAENORHABDITIS-ELEGANS AND LOWER GOMPERTZ RATE OF AGING
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DOI：
10.1126/science.2392681
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发表时间：
1990-08-24
期刊：
影响因子：
56.9
通讯作者：
JOHNSON, TE
中科院分区：
文献类型：
--
作者：
JOHNSON, TE
线虫秀丽隐杆线虫的age-1基因的突变已显示在25 ℃时导致平均寿命增加65%和最大寿命增加110%。C.器官老化和衰老过程的标志之一是年龄特异性死亡率随实足年龄呈指数加速。这种指数加速是在遗传控制下：年龄1突变雌雄同体显示出50%的死亡率与实足年龄比野生型菌株的加速。突变雄性也表现出寿命延长和死亡率加速的速度减慢，虽然年龄-1突变雄性仍然有显着较短的寿命比雌雄同体的相同基因型。较慢的死亡率加速是隐性特征的年龄-1突变等位基因检查。
A mutation in the age-1 gene of the nematode Caenorhabditis elegans has been shown to result in a 65 percent increase in mean life-span and a 110 percent increase in maximum life-span at 25.degree. C. One of the hallmarks of organismic aging and senescent processes is an exponential acceleration of age-specific mortality rate with chronological age. This exponential acceleration is under genetic control: age-1 mutant hermaphrodites show a 50 percent slower rate of acceleration of mortality with chronological age than wild-type strains. Mutant males also show a lengthening of life and a slowing of the rate of acceleration of mortality, although age-1 mutant males still have significantly shorter life-spans than do hermaphrodites of the same genotype. The slower rates of acceleration of mortality are recessive characteristics of the age-1 mutant alleles examined.