The ratio of second- and fourth-digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency
The ratio of second- and fourth-digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency
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DOI：
10.1016/s0378-3782(02)00073-7
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发表时间：
2002-12-01
影响因子：
2.5
通讯作者：
Yaris, N
中科院分区：
文献类型：
--
作者：
Ökten, A;Kalyoncu, M;Yaris, N
21-羟化酶缺乏导致的先天性肾上腺增生（CAH）导致女性胎儿在妊娠期过度暴露于雄激素和不同程度的外生殖器男性化。宫内促性腺激素不仅对生殖器官的发育至关重要，而且还会影响其他生殖器官的发育。第二和第四手指的比例（2D/4D）显示出两性二态模式，男性的第四手指比女性的第二手指长。低2D/4D比例与高精子数量、睾丸激素水平和男性生殖成功率有关。2D/4D比值高与女性雌激素水平高有关。第二和第四指的比例还被发现与性取向、左手偏好、自闭症和一些成人发病疾病（如乳腺癌和心肌梗塞）有关。我们发现21-羟化酶缺乏症女性患者的2D/4D比低于健康女孩（p = 0.000），与男性对照组相比，女性患者的2D/4D比相同。男性21-羟化酶缺乏症患者右手2D/4D比值明显低于女性和男性对照组。健康男孩的2D/4D比值低于健康女孩。由此可见，宫内雄激素水平决定的2D/4D比值影响两性二形指型。(C) 2002爱思唯尔科学爱尔兰有限公司版权所有。
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency results in excessive androgen exposure in the gestational period and various degrees of masculinization of the external genitalia in female foetuses. Intrauterine gonadal steroids are not only essential for the development of the genital organs but also affect some other extragenital organ development.The second to fourth digit (2D/4D) ratio shows a sexually dimorphic pattern with longer fourth digit from second digit in men compared to women. A low 2D/4D ratio is associated with high sperm count, testosterone levels and reproductive success in men. A high 2D/4D ratio is associated with high oestrogen levels in women. Second and fourth digit ratio has also found to be correlated with sexual orientation, left hand preference autism and some adult onset diseases such as breast cancer and myocardial infarction.We found lower 2D/4D ratio in female patients with 21-hydroxylase deficiency compared to healthy girls (p = 0.000) and equal 2D/4D ratio for female patients when compared to male controls. Male patients with 21-hydroxylase deficiency had significantly lower 2D/4D ratio than female and male controls in the right hand. Healthy boys had lower 2D/4D ratio than healthy girls.It is concluded that 2D/4D ratio established by intrauterine androgen levels influences the sexually dimorphic digit pattern. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.