[Research progress on chemical constituents, pharmacological mechanism and clinical application of Guizhi decoction].
[Research progress on chemical constituents, pharmacological mechanism and clinical application of Guizhi decoction].
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DOI：
10.19540/j.cnki.cjcmm.20170928.010
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发表时间：
2017-12
期刊：
影响因子：
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通讯作者：
Haijian Yuan;Wei Li;Jian-Ming Jin;Jing-Jing Chen-Jing;Jun Jiang;Hui Wang;Xiao-Bin Jia;Liang Feng
中科院分区：
文献类型：
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作者：
Haijian Yuan;Wei Li;Jian-Ming Jin;Jing-Jing Chen-Jing;Jun Jiang;Hui Wang;Xiao-Bin Jia;Liang Feng
桂枝汤是临床常用的中药之一，具有解肌法标、调理营卫的作用。主要用于治疗发热、头痛、多汗、恶风等外感寒证。现代研究表明，桂枝汤的化学成分主要有苯丙素、单萜类、有机酸、黄酮类、三萜皂苷等。药理实验研究表明，桂枝汤对汗腺、体温、免疫功能、胃肠蠕动、血压等具有双向调节作用，并具有抗炎、抗菌、抗病毒、抗过敏、镇痛、降血糖、心血管保护等作用。临床上运用桂枝汤及其类似方剂治疗内科、外科学、妇科、儿科等多种疾病，涉及循环、免疫、泌尿、生殖、内分泌、消化、神经等多个系统。本文从桂枝汤的化学成分、药理作用机制和临床应用三个方面综述了桂枝汤的最新研究进展。为桂枝汤的进一步研究和开发提供参考。
Guizhi Decoction was one of the most commonly used traditional Chinese Medicine which possesses the effects of "jie-ji-fa-biao, regulating Ying and Wei". It was mainly used to treat mind-cold due to exogenous evils such as fever, headache, sweating, hate the wind, et al. Modern studies indicated that the chemical constituents of Guizhi decoction mainly include phenylpropanoid, monoterpenes, organic acids, flavonoids, triterpenoid saponins and so on. Pharmacological experimental studies had shown that Guizhi decoction could play a big role in dual-directional regulation on sweat gland, body temperature, immune function, gastrointestinal peristalsis, and blood pressure, and could also play the role of anti-inflammatory, antibacterial, antiviral, anti-allergic, analgesic, hypoglycemic, and cardiovascular protection. Many diseases such as internal, external, gynecological and pediatric diseases were treated in the clinical by using Guizhi decoction and its analogous formulae involving circulatory, immune, urinary, reproductive, endocrine, digestive, nervous and other systems. This article reviews the latest research progress of Guizhi decoction from three aspects: chemical constituents, pharmacological mechanism and clinical application. It will provide reference for further research and development of Guizhi decoction.