Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex
Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex
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DOI：
10.1152/ajpheart.00556.2010
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发表时间：
2010-11-01
影响因子：
4.8
通讯作者：
Farquhar, William B.
中科院分区：
文献类型：
--
作者：
Delaney, Erin P.;Greaney, Jody L.;Farquhar, William B.
Delaney EP, Greaney JL, Edwards DG, Rose WC, Fadel PJ, Farquhar WB。老年高血压患者对握力运动的过度交感神经和压力反应：肌肉代谢反射的作用。[J]中国生物医学工程学报，2016,31(2):555 - 557。首次发表于2010年8月27日；doi: 10.1152 / ajpheart.00556.2010。-最近的动物研究报道，运动加压反射（EPR）介导的血压升高在高血压（HTN）啮齿动物中被夸大。这些发现是否可以推广到人类高血压还不清楚。测量正常血压（NTN; n = 23； 60 +/- 1年）和HTN （n = 15； 63 +/- 1年）受试者在基线时的平均动脉压（MAP）、肌肉交感神经活动（MSNA）和静脉代谢物，以及在30%和40%最大自愿收缩（MVC）时的静态握力，随后是一段时间的运动后缺血（PEI），以分离EPR的代谢成分。HTN受试者在30%和40% MVC握拍期间MAP较基线的变化均有所增加（两者均P < 0.05），并且在PEI期间保持这些组间差异（30% PEI试验：Delta 15 +/-2 NTN vs Delta 19 +/-2 HTN mmHg； 40% PEI试验：Delta 16 +/- 1 NTN vs Delta 23 +/-2 HTN mmHg；两者均P < 0.05）。同样，在HTN受试者中，在30%和40% MVC握拍时MSNA爆发频率更高（两者均P < 0.05），并且在PEI期间保持这种差异[30% PEI试验：35 +/- 2 (NTN) vs. 44 +/- 2 （HTN）脉冲/min；40% PEI试验：36次+/- 2次（NTN） vs. 48次+/- 2次(HTN) /min；P < 0.05]。代谢物未见组间差异。MAP和MSNA对冷压试验的反应在两组之间没有差异，表明在广义交感反应上没有组间差异。总之，与NTN受试者相比，HTN成人在PEI期间对握力运动表现出夸大的交感神经和压力反应，表明老年HTN人群中EPR代谢成分的激活增强。
Delaney EP, Greaney JL, Edwards DG, Rose WC, Fadel PJ, Farquhar WB. Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex. Am J Physiol Heart Circ Physiol 299: H1318-H1327, 2010. First published August 27, 2010; doi:10.1152/ajpheart.00556.2010.-Recent animal studies have reported that exercise pressor reflex (EPR)-mediated increases in blood pressure are exaggerated in hypertensive (HTN) rodents. Whether these findings can be extended to human hypertension remains unclear. Mean arterial pressure (MAP), muscle sympathetic nerve activity (MSNA), and venous metabolites were measured in normotensive (NTN; n = 23; 60 +/- 1 yr) and HTN (n = 15; 63 +/- 1 yr) subjects at baseline, and during static handgrip at 30 and 40% maximal voluntary contraction (MVC) followed by a period of post-exercise ischemia (PEI) to isolate the metabolic component of the EPR. Changes in MAP from baseline were augmented in HTN subjects during both 30 and 40% MVC handgrip (P < 0.05 for both), and these group differences were maintained during PEI (30% PEI trial: Delta 15 +/- 2 NTN vs. Delta 19 +/-2 HTN mmHg; 40% PEI trial: Delta 16 +/- 1 NTN vs. Delta 23 +/- 2 HTN mmHg; P < 0.05 for both). Similarly, in HTN subjects, MSNA burst frequency was greater during 30 and 40% MVC handgrip (P < 0.05 for both), and these differences were maintained during PEI [30% PEI trial: 35 +/- 2 (NTN) vs. 44 +/- 2 (HTN) bursts/min; 40% PEI trial: 36 +/- 2 (NTN) vs. 48 +/- 2 (HTN) bursts/min; P < 0.05 for both]. No group differences in metabolites were observed. MAP and MSNA responses to a cold pressor test were not different between groups, suggesting no group differences in generalized sympathetic responsiveness. In summary, compared with NTN subjects, HTN adults exhibit exaggerated sympathetic and pressor responses to handgrip exercise that are maintained during PEI, indicating that activation of the metabolic component of the EPR is augmented in older HTN humans.