Fabrication of angstrom-scale two-dimensional channels for mass transport
Fabrication of angstrom-scale two-dimensional channels for mass transport
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DOI：
10.1038/s41596-023-00911-x
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发表时间：
2023-11
期刊：
影响因子：
14.8
通讯作者：
Ankit Bhardwaj;Marcos Vinicius Surmani Martins;Yi You;Ravalika Sajja;Max Rimmer;S. Goutham;Rongrong Qi;Sidra Abbas Dar;Boya Radha;A. Keerthi
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文献类型：
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作者：
Ankit Bhardwaj;Marcos Vinicius Surmani Martins;Yi You;Ravalika Sajja;Max Rimmer;S. Goutham;Rongrong Qi;Sidra Abbas Dar;Boya Radha;A. Keerthi
在原子尺度上的荧光通道调节细胞的运输和跨膜的分子过滤，因此在生命系统的功能中起着至关重要的作用。然而，由于纳米纤维技术的局限性和常用材料的表面粗糙度，在这些尺度上实验性地构建合成通道一直是一个重大挑战。埃（Angstrom）尺度的狭缝状通道克服了这些挑战，因为这些通道是在精确控制其尺寸的情况下制成的，并且可以用于以前所未有的规模研究气体、离子和水的流体特性。在这里，我们提供了一个详细的制造方法的二维纳米尺度的通道设备，可以组装包含所需数量的通道，一个单一的通道或多达数百个通道，原子级精度使用层状晶体制成。该过程包括基底、薄片、间隔层、薄片转移、货车德瓦尔斯组装和后处理的制造。我们进一步解释了如何使用双通道进行分子输运测量，以直接探测有助于揭示超受限输运物理学的有趣和异常现象。该过程需要总共1-2周的时间来制造二维通道装置，并且适合于具有洁净室工作环境和纳米制造的先前经验的用户。
Fluidic channels at atomic scales regulate cellular trafficking and molecular filtration across membranes, and thus play crucial roles in the functioning of living systems. However, constructing synthetic channels experimentally at these scales has been a significant challenge due to the limitations in nanofabrication techniques and the surface roughness of the commonly used materials. Angstrom (Å)-scale slit-like channels overcome such challenges as these are made with precise control over their dimensions and can be used to study the fluidic properties of gases, ions and water at unprecedented scales. Here we provide a detailed fabrication method of the two-dimensional Å-scale channel devices that can be assembled to contain a desired number of channels, a single channel or up to hundreds of channels, made with atomic-scale precision using layered crystals. The procedure includes the fabrication of the substrate, flake, spacer layer, flake transfers, van der Waals assembly and postprocessing. We further explain how to perform molecular transport measurements with the Å-channels to directly probe the intriguing and anomalous phenomena that help shed light on the physics governing ultra-confined transport. The procedure requires a total of 1–2 weeks for the fabrication of the two-dimensional channel device and is suitable for users with prior experience in clean room working environments and nanofabrication.