T resident helper cells promote humoral responses in the lung.
T resident helper cells promote humoral responses in the lung.
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DOI：
10.1126/sciimmunol.abb6808
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发表时间：
2021-01-08
影响因子：
24.8
通讯作者：
King CG
中科院分区：
文献类型：
--
作者：
Swarnalekha N;Schreiner D;Litzler LC;Iftikhar S;Kirchmeier D;Künzli M;Son YM;Sun J;Moreira EA;King CG
Influenza is a deadly and costly infectious disease, even during flu seasons when an effective vaccine has been developed. To improve vaccines against respiratory viruses, a better understanding of the immune response at the site of infection is crucial. After influenza infection, clonally expanded T cells take up permanent residence in the lung, poised to rapidly respond to subsequent infection. Here, we characterized the dynamics and transcriptional regulation of lung-resident CD4+ T cells during influenza infection and identified a long-lived, Bcl6-dependent population that we have termed T resident helper (TRH) cells. TRH cells arise in the lung independently of lymph node T follicular helper cells but are dependent on B cells, with which they tightly colocalize in inducible bronchus-associated lymphoid tissue (iBALT). Deletion of Bcl6 in CD4+ T cells before heterotypic challenge infection resulted in redistribution of CD4+ T cells outside of iBALT areas and impaired local antibody production. These results highlight iBALT as a homeostatic niche for TRH cells and advocate for vaccination strategies that induce TRH cells in the lung.
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影响因子：
24.8
作者：
Kuenzli, Marco;Schreiner, David;King, Carolyn G.
通讯作者：
King, Carolyn G.
影响因子：
64.8
作者：
Helmink BA;Reddy SM;Gao J;Zhang S;Basar R;Thakur R;Yizhak K;Sade-Feldman M;Blando J;Han G;Gopalakrishnan V;Xi Y;Zhao H;Amaria RN;Tawbi HA;Cogdill AP;Liu W;LeBleu VS;Kugeratski FG;Patel S;Davies MA;Hwu P;Lee JE;Gershenwald JE;Lucci A;Arora R;Woodman S;Keung EZ;Gaudreau PO;Reuben A;Spencer CN;Burton EM;Haydu LE;Lazar AJ;Zapassodi R;Hudgens CW;Ledesma DA;Ong S;Bailey M;Warren S;Rao D;Krijgsman O;Rozeman EA;Peeper D;Blank CU;Schumacher TN;Butterfield LH;Zelazowska MA;McBride KM;Kalluri R;Allison J;Petitprez F;Fridman WH;Sautès-Fridman C;Hacohen N;Rezvani K;Sharma P;Tetzlaff MT;Wang L;Wargo JA
通讯作者：
Wargo JA
影响因子：
6.7
作者：
Laidlaw BJ;Decman V;Ali MA;Abt MC;Wolf AI;Monticelli LA;Mozdzanowska K;Angelosanto JM;Artis D;Erikson J;Wherry EJ
通讯作者：
Wherry EJ
影响因子：
32.4
作者：
Heesters, Balthasar A.;Chatterjee, Priyadarshini;Carroll, Michael C.
通讯作者：
Carroll, Michael C.
影响因子：
64.8
作者：
Cabrita, Rita;Lauss, Martin;Jonsson, Goran
通讯作者：
Jonsson, Goran