Relation between adaptive function and IQ among youth with histories of heavy prenatal alcohol exposure
Relation between adaptive function and IQ among youth with histories of heavy prenatal alcohol exposure
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DOI：
10.1002/bdr2.1463
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发表时间：
2019-07-15
影响因子：
2.1
通讯作者：
Mattson, Sarah N.
中科院分区：
文献类型：
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作者：
Doyle, Lauren R.;Coles, Claire D.;Mattson, Sarah N.
自适应功能和一般智力功能是两个重要且经常相互关联的领域。虽然产前酒精暴露的青少年经常表现出这两个领域的损伤，但尚不清楚这些领域之间的关系是否在能力水平上是一致的，或者例如，适应功能是否受更高能力水平的智力功能的影响较小。当前研究的目的是在产前是否有酒精暴露的青少年中测试这种关系。方法作为第二阶段胎儿酒精谱系障碍合作倡议的一部分，重度产前酒精暴露（AE）和有或无其他临床状况或担忧（CON）的非暴露受试者完成了一项全面的神经行为测试。多元回归分析检验了全量表智商（FSIQ）与整体适应功能的关系。创建组和每个变量之间的交互项，以正式检验组差异。随后的三个回归分析测试了哪些适应功能域（沟通、日常生活技能、社会化）对结果有显著影响。后续分析检查了基于智商范围（低智商= 85）的相关性。结果FSIQ与组间整体适应功能交互作用显著；AE组FSIQ与适应功能的关系弱于CON组。对于特定的自适应功能域，FSIQ和Group之间的交互作用仅在Communication域显著。随访分析显示，在低智商范围内，CON组的FSIQ与Communication的相关性强于AE组。在高智商范围内，FSIQ与沟通之间的相关性仅在CON组中显著。结论：虽然在对照组中，较高的智力功能与较好的适应功能能力相关，但在酒精暴露的青少年中没有发现这种情况，他们发现适应能力普遍下降。此外，群体之间的智商和适应功能之间的差异关系似乎是由沟通能力驱动的。这些发现表明，产前酒精暴露儿童的智力功能水平并不能完全解释照顾者报告的沟通和整体适应功能缺陷，特别是在功能水平较高的情况下。
Background Adaptive function and general intellectual function are two important and often correlated domains. While youth with prenatal alcohol exposure frequently demonstrate impairments in both domains, it is not clear whether the relation between these domains is consistent across levels of ability or whether, for example, adaptive function is less affected by intellectual function at higher ability levels. The aim of the current study was to test this relation in youth with and without prenatal alcohol exposure. Methods As part of the Collaborative Initiative on Fetal Alcohol Spectrum Disorders, Phase II, subjects with heavy prenatal alcohol exposure (AE) and nonexposed subjects with and without other clinical conditions or concerns (CON) completed a comprehensive neurobehavioral battery. Multiple regression analyses tested the relation between full scale IQ (FSIQ) and overall adaptive function. Interaction terms between Group and each variable were created to formally test for group differences. Three subsequent regression analyses tested which adaptive function domains (Communication, Daily Living Skills, Socialization) significantly contributed to results. Follow-up analyses examined correlations based on IQ range (low IQ = 85). Results The interaction between FSIQ and Group on overall adaptive function was significant; the relationship between FSIQ and adaptive function was weaker in the AE group than in the CON group. Regarding specific adaptive function domains, the interaction between FSIQ and Group was significant only in the Communication domain. Follow-up analyses showed, within the low IQ range, the correlation between FSIQ and Communication was stronger in the CON group than the AE group. Within the high IQ range, the correlation between FSIQ and Communication was significant only in the CON group. Conclusions Although higher intellectual functioning was associated with better adaptive function ability among controls, this was not found among the alcohol-exposed youth where a general dampening of adaptive ability was noted. Further, the differential relationship between IQ and adaptive function between groups appears to be driven by communication abilities. These findings suggest that level of intellectual functioning of children with prenatal alcohol exposure does not fully account for caregiver-reported communication and overall adaptive function deficits particularly at higher levels of functioning.