A role for intraluteal estrogen in the mediation of luteinizing hormone action on the rat corpus luteum during pregnancy.
A role for intraluteal estrogen in the mediation of luteinizing hormone action on the rat corpus luteum during pregnancy.
复制标题
黄体内雌激素在介导妊娠期间大鼠黄体黄体生成激素作用中的作用。
DOI：
10.1210/endo-103-1-162
复制
发表时间：
1978
期刊：
影响因子：
4.8
通讯作者：
J. Richards
中科院分区：
文献类型：
--
作者：
G. Gibori;P. Keyes;J. Richards
The ability of rat corpora lutea to accumulate estradiol via aromatization of testosterone suggests that estradiol might have a direct role in the regulation of luteal function. Rats were treated with LH antiserum on day 10 of pregnancy or with LH antiserum plus testosterone which was administered by a testosterone- filled Silastic capsule implanted sc on day 9 and left in place until the end of the experiment on day 14. In rats treated with LH antiserum alone, serum progesterone, luteal estradiol content, and luteal cell nuclear content of estradiol receptor had decreased sharply within 24 h, whereas luteal LH receptor remained elevated. Treatment with LH antiserum plus a large testosterone implant prevented the decline in serum progesterone and nuclear estradiol receptor and caused a dramatic elevation in luteal estradiol content. By day 14, rats treated with antiserum alone had aborted, LH receptor content was reduced 92%, serum progesterone was 7 ± 1 ng/ml, luteal estradiol concentration 5 ± 7 pg/mg t...
